ID G1TLY1_RABIT Unreviewed; 612 AA.
AC G1TLY1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=TBK1 binding protein 1 {ECO:0000313|Ensembl:ENSOCUP00000017985.2};
GN Name=TBKBP1 {ECO:0000313|Ensembl:ENSOCUP00000017985.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000017985.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000017985.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000017985.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000017985.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000017985.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02039618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02039619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TLY1; -.
DR SMR; G1TLY1; -.
DR STRING; 9986.ENSOCUP00000017985; -.
DR PaxDb; 9986-ENSOCUP00000017985; -.
DR Ensembl; ENSOCUT00000029804.3; ENSOCUP00000017985.2; ENSOCUG00000014771.4.
DR eggNOG; ENOG502QVP4; Eukaryota.
DR GeneTree; ENSGT00940000153704; -.
DR HOGENOM; CLU_029090_0_0_1; -.
DR InParanoid; G1TLY1; -.
DR OMA; QRHSPIQ; -.
DR TreeFam; TF331289; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000014771; Expressed in frontal cortex and 15 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR024581; TBD.
DR PANTHER; PTHR14432; PROSAPIP2 PROTEIN/5-AZACYTIDINE INDUCED GENE 2; 1.
DR PANTHER; PTHR14432:SF2; TANK-BINDING KINASE 1-BINDING PROTEIN 1; 1.
DR Pfam; PF12845; TBD; 1.
DR PROSITE; PS51905; ZF_UBZ1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT DOMAIN 580..606
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT REGION 329..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 48..75
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 103..140
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 226..274
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 343..436
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 67349 MW; 4F07CBFAD401E886 CRC64;
MESMFEEDIS ILTQEALGPS EVWLDGPGDP SLGGDMCSAS HFALITAYGD IKERLGGLER
ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKEGSLLE VEKVSLQQRL NQFQQELQRN
KEQEEQLGEM IQAYEKLCVE KSDLETELGE MRALVETHLR QICGLEQQLR QQQGLRDAAF
PSLSPPPAPA PPCADLDLHY LALRGGSALS HAGWPGPVPS VGELERRRLE EALEAAQGEA
RGAQLREEQL QAECERLQGE LKQLQESRAQ DLASNQSERD MAWVKRIGDD QVNLALAYTE
LTEELGRLRE LSSLQGRILR TLLQEQARSC GQRHSPLSQR HSPAPQCPSP SPPARAAPPC
QSPRPAAPLA RAPVPPRPSS AARPPRPRAR RPSPQRRSPV PPPCQSPSPQ RRSPVPPSCP
APQPRPPPPP PPPADRTLAE RAYAKPPSHH VKAGFQGRRS YSELAEGAAY AGASPAWLQA
EAATLPKPRT YGGELYGPAR PLSPRRAFEG IRLRFEKQPS EEEEWAVPAS PPSPEAGTIR
CASFCAGFPI PESPAAYAHA EHAQSWPSIN LLMETVGSDI RSCPLCQLGF PVGYPDDALI
KHIDSHLENS KI
//
