ID G1TSN1_RABIT Unreviewed; 1703 AA.
AC G1TSN1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=ATP binding cassette subfamily A member 3 {ECO:0000313|Ensembl:ENSOCUP00000020049.1};
GN Name=ABCA3 {ECO:0000313|Ensembl:ENSOCUP00000020049.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000020049.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000020049.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000020049.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000020049.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017195078.1; XM_017339589.1.
DR PaxDb; 9986-ENSOCUP00000020049; -.
DR Ensembl; ENSOCUT00000021903.3; ENSOCUP00000020049.1; ENSOCUG00000005137.4.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000155289; -.
DR HOGENOM; CLU_000604_19_1_1; -.
DR OMA; VCPQDDA; -.
DR OrthoDB; 6951at2759; -.
DR TreeFam; TF105191; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000005137; Expressed in upper lobe of left lung and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF98; PHOSPHOLIPID-TRANSPORTING ATPASE ABCA3; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1099..1119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1140..1166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1178..1202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1214..1234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 529..762
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1380..1613
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1703 AA; 190220 MW; 02201475B7A568FC CRC64;
MAVLRQLALL LWKNYTLQKR KVLVTALELF LPLLFSGILI WLRLKIQSEN VPNATVYPGQ
SIQELPLFFN FPPPGDAWEL AYIPSHSDAA RAITEWARRA LVVNMKVRGF PSEKHFEDYI
RYDNRSSNVL AALVFENEFS HSTDPLPLAV KYHLRFSYTR RNYMWTQSGT FLLRDTEGWH
TNSLFPLFPN PGPREPASPD GGEPGYVREG FLAVQHAVDR AIMHYHANAS AQQLLQQLTV
TVKRFPYPPF ISDPFLVAIQ YQLPLLLLLS FTYASLTIIR AVVQEKERKL KEYMRMLGLD
SWVHWNAWFL MFFLVLLVVV SFMTLLFCVK VKTGVAVLTN SDPSLVLAFL LCFATSSISF
SFMVSTFFSK ANMAAAIGGF LYFFTYTPYF FVAPRYNWMA LSQKLLSCLL SNVAMAMGAQ
LIGKFEAKGT GIQWRDLLSP VSVDDDFCFG HVLGLLLLDS VLYGLVTWYV EAVFPGQFGV
PQPWYFFIMP SYWCGSPRTA LGKEEDADPE KALPTEHCEA EPEALVAGIK IKHLSKVFRV
GNKDRAAVRD LNLNLYEGQV TVLLGHNGAG KTTTLSMLTG LFPPTSGQAY ISGYEISQDM
PQIRKSLGLC PQHDVLFDNL TVEEHLSFYA QLKGLSPHKC PEEVKQMLHV LSLEDKRDSR
CRFLSGGMKR KLSVGIALIA GSKVLMLDEP TSGMDAISRR AVWDLLQQQK SDRTILLTTH
FMDEADLLGD RIAIMAKGEL QCCGSPLFLK QKYGAGYHMT LVKEPHCNPA GVSQLVRHHV
PNATLESSAG AELSFILPKE STHRFESLFA KLEKRQKELG IASFGASVTT MEEVFLRVGK
LVDTSMDIQA VQLPALQYQH ERRASDWAVD SSLCGALDPT DGIGALIEEE PSMVKLNTGL
ALHWQQFWAM FLKKATYSWR EWKMLAAQIL VPLTCVTLAL LAINYSSEIL DDPLLRLTLG
EYGRTVVPFS VPGTSRLDQQ LSERLKDMLQ AQGQEPREVL GDLEEFLIFR ASVEGGGFNE
RCLVAMSFGD AGEHTVVTAL FNNQAYHSPA TALAVVDNLL FQLLCGPRAS IEVSNYPQPR
SALQAAKDQF SEGRKGFDIA LNLLFAMAFL TSTFSILAVS ERAVQAKHVQ FVSGVRVATY
WLSALLWDLI SFLVPSLLLL AVFRAFDVRA FTWDGHAAGT LLLLLLYGWA IIPLMYLMSF
LFSSAATAYT RLTIFNVLSG IATFLMVTIM RIPAVKLEEL ARTLDRVFLV LPNHCLGMAV
SSFYENYETK HYCTSSEIAA HYCKKFNIVY QENFFAWSAP GVGRFVTSMA ASGCAYLTLL
FLIETDLLWR LRNSVCAFRR RWTLAELCAQ TALLPEDQDV AEERSRVLAP SLGPLLDAPL
IIKELSKVYE QRTPLLAVDK ISLAVQRGEC FGLLGFNGAG KTTTFKMLTG EESITSGDAF
VGGHSISSDI GKVRQRIGYC PQFDALLDHM TGREMLVMYA RLRGIPERHI GACVENTLRG
LLLEPHANKL VRTYSGGNKR KLSTGIALLG EPAVIFLDEP STGMDPVARR LLWDTVARAR
ESGKAVVITS HSMEECEALC TRLAIMVQGQ FKCLGSPQHL KSKFGSGYSL QAKVRSRGQQ
EALRDFKAFV DLTFPGSVLE DEHQGMVHYH LPGHDLSWAK VFGTLEKAKE KYGVDDYSVS
QISLEQVFLS FAHLQPPTSE EGR
//
