ID G1U2U2_RABIT Unreviewed; 571 AA.
AC G1U2U2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Arylsulfatase family member I {ECO:0000313|Ensembl:ENSOCUP00000023695.2};
GN Name=ARSI {ECO:0000313|Ensembl:ENSOCUP00000023695.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000023695.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000023695.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000023695.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000023695.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000023695.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; AAGW02027431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002710353.1; XM_002710307.3.
DR AlphaFoldDB; G1U2U2; -.
DR SMR; G1U2U2; -.
DR STRING; 9986.ENSOCUP00000023695; -.
DR PaxDb; 9986-ENSOCUP00000023695; -.
DR Ensembl; ENSOCUT00000029772.3; ENSOCUP00000023695.2; ENSOCUG00000025005.3.
DR GeneID; 100343638; -.
DR KEGG; ocu:100343638; -.
DR CTD; 340075; -.
DR eggNOG; KOG3867; Eukaryota.
DR GeneTree; ENSGT00940000157656; -.
DR HOGENOM; CLU_006332_10_1_1; -.
DR InParanoid; G1U2U2; -.
DR OMA; WDWMKPS; -.
DR OrthoDB; 2913702at2759; -.
DR TreeFam; TF314186; -.
DR Proteomes; UP000001811; Chromosome 3.
DR Bgee; ENSOCUG00000025005; Expressed in aorta and 14 other cell types or tissues.
DR GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:UniProt.
DR CDD; cd16029; 4-S; 1.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR047115; ARSB.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR PANTHER; PTHR10342:SF68; ARYLSULFATASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
DR PROSITE; PS00149; SULFATASE_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..571
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003423205"
FT DOMAIN 47..359
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT REGION 508..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 64066 MW; AB0C021BC0A5A211 CRC64;
MHALTGLSLV SLLSFGYLSW DWARPSLMAD APAEAGAPPS AAPPQPPHII FILTDDQGYH
DVGYHGSDIE TPTLDRLAAE GVKLENYYIQ PICTPSRSQL LTGRYQIHTG LQHSIIRPRQ
PNCLPLDQVT LPQKLQEAGY STHMVGKWHL GFYRKECLPT RRGFDTFLGS LTGNVDYYTY
DNCDGPGVCG FDLHEGESVA WGLSGQYSTM LYAQRASHIL ASHSPRRPLF LYVAFQAVHT
PLQSPREYLY RYRTMGNVAR RKYAAMVTCM DEAVRNITWA LKRYGFYNNS VIIFSSDNGG
QTFSGGSNWP LRGRKGTYWE GGVRGLGFVH SPLLKRKRRT SRALVHITDW YPTLVGLAGG
SASAADGLDG YDVWPAISEG RASPRTEILH NIDPLYNHAQ HGSLEGGFGI WNTAVQAAIR
VGEWKLLTGD PGYGDWIPPQ TLASFPGSWW NLERMASVRQ AVWLFNISAD PYEREDLAGQ
RPDVVRTLLA RLADYNRTAI PVRYPAENPR AHPDFNGGAW GPWASDEDEE EEEEGGRARS
FSRGRRKKKC KICKLRSFFR KLNTRLMSHR I
//
