ID G1U312_RABIT Unreviewed; 1212 AA.
AC G1U312;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Dermatan sulfate epimerase like {ECO:0000313|Ensembl:ENSOCUP00000023769.2};
GN Name=DSEL {ECO:0000313|Ensembl:ENSOCUP00000023769.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000023769.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000023769.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000023769.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000023769.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000023769.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dermatan-sulfate isomerase family.
CC {ECO:0000256|ARBA:ARBA00006556}.
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DR EMBL; AAGW02050774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017199715.1; XM_017344226.1.
DR AlphaFoldDB; G1U312; -.
DR SMR; G1U312; -.
DR PaxDb; 9986-ENSOCUP00000023769; -.
DR Ensembl; ENSOCUT00000010666.3; ENSOCUP00000023769.2; ENSOCUG00000010669.3.
DR GeneID; 100341351; -.
DR CTD; 92126; -.
DR eggNOG; ENOG502QPWZ; Eukaryota.
DR GeneTree; ENSGT00390000006522; -.
DR HOGENOM; CLU_011348_0_0_1; -.
DR InParanoid; G1U312; -.
DR OrthoDB; 2897792at2759; -.
DR TreeFam; TF334118; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000010669; Expressed in aorta and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 2.70.98.70; -; 1.
DR Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008929; Chondroitin_lyas.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR15532; -; 1.
DR PANTHER; PTHR15532:SF2; DERMATAN-SULFATE EPIMERASE-LIKE PROTEIN; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF48230; Chondroitin AC/alginate lyase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1212
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023898216"
FT TRANSMEM 764..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 853..1161
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
SQ SEQUENCE 1212 AA; 139116 MW; CEEF15A2716A66CB CRC64;
MALMFIGHFL FLALVMFGFS TLEESVSNYS EWAVFTDDIN QFKTQKVQDF KANQKLKKSM
LHPSLYFDAG EIQSMRQKSH TSHLHLFRAI RSAVTVMLSN PTYYLPPPKH ADFAAKWNEI
YGNNLPPLAL YCLLSPEDKV AFEFVLEYMD RMVGYKDWLV ENAPGDEVPI GHSLTGFATA
FDFLYNLLDN HRRQIYLEKI WIITEEMYEY SKVRSWGKQL LHNHQATNMI ALLTGALVTG
VEKGSKANIW KQVVVDVMEK TMFLLNHVVD GSLDEGVAYG SYTAKSVTQY VFLAQRHFNI
NNLDNNWLKM HFWFYYATLL PGFQRTVGIA DSNYNWFYGP ESQLVFLDKF ILKNGAGNWL
AQQIRKHRPK DGPMVPSTAQ RWSTLHTEYI WYDPQLTPQP PAEYGTAKMH TFPNWGVVTY
GAGLPNTQTN TFVSFKSGKL GGRAVYDIVH FQPYSWIDGW RSFNPGHEHP DQNSFTFAPN
GQVFVSEALY GPKLSHLNNV LVFAPSPSSQ CNKPWEGQLG ECAQWLKWTG EEVGDAAGEI
ITASQHGEMI FVSGEAVSAY SSAMRLKSVY RALLLLNSQT LLVVDHIERQ EDSPINSVSA
FFHNLDIDFK YIPYKFRNSY NGAMMDVWDA HYKMFWFDHH GNSPTASIQE AEQAAEFKKR
WTQFVNVTFQ MESTITRIAY IFYGPYVNVS GCRFIDNSNS GLQISLSVNN SEHVVSIVTD
YHNLKTRFNY LGFGGFANVA DESQITRFGL GTQAIVKPVR HDRVIFPFGF KFNIAVGFIL
CISLVILTFQ WRFYLSFRKL MRWILILVIA LWFIELLDVW STCTQPICAK WTRAEAEASK
KALSPEGYHV DLPDVVITSL PGSGAEILKQ LFFNSSDFLY IRVPTAYIDI PETEFEIDSF
VDACEWKVSD IRSGHFRLLR GWLQSLVRDT KLHLQNIHLH EPSKGKLAQY FTANKEKKRK
LKRKESLLEQ RSRMKGAFDR DAEYIRALRR HLVYYPSARP VLSLNSGSWT LKLHFFQEVL
GTSMRALYVV RDPRAWIYSM LYSSKPSFYS LKNVPEHLAK LFKVDGGKGK CSLNSGYAFE
YEPLKKELSK SKSNAVSLLS HLWLANTAAA LRINTDLLPT SYQLVKFEDI VHFPQKTTER
IFAFLGIPLS PASLNQILFA TSTNLFYLPY EGEISPTNTN VWKQNLPRDE IKLIENICWT
LMDRLGYPKF MD
//
