ID G1WFR2_9ACTN Unreviewed; 454 AA.
AC G1WFR2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 13-SEP-2023, entry version 60.
DE RecName: Full=Diaminopimelate decarboxylase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF9452_00175 {ECO:0000313|EMBL:EGX67854.1};
OS Collinsella tanakaei YIT 12063.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC Coriobacteriaceae; Collinsella.
OX NCBI_TaxID=742742 {ECO:0000313|EMBL:EGX67854.1, ECO:0000313|Proteomes:UP000004830};
RN [1] {ECO:0000313|EMBL:EGX67854.1, ECO:0000313|Proteomes:UP000004830}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIT 12063 {ECO:0000313|EMBL:EGX67854.1,
RC ECO:0000313|Proteomes:UP000004830};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Morotomi M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Collinsella tanakaei YIT 12063.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR600183-50};
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC {ECO:0000256|RuleBase:RU003737}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGX67854.1}.
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DR EMBL; ADLS01000004; EGX67854.1; -; Genomic_DNA.
DR RefSeq; WP_009140212.1; NZ_JH126467.1.
DR AlphaFoldDB; G1WFR2; -.
DR STRING; 742742.HMPREF9452_00175; -.
DR GeneID; 62757962; -.
DR PATRIC; fig|742742.3.peg.171; -.
DR eggNOG; COG0019; Bacteria.
DR HOGENOM; CLU_026444_0_2_11; -.
DR OrthoDB; 9802241at2; -.
DR Proteomes; UP000004830; Unassembled WGS sequence.
DR GO; GO:0008836; F:diaminopimelate decarboxylase activity; IEA:InterPro.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro.
DR CDD; cd06828; PLPDE_III_DapDC; 1.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR InterPro; IPR002986; DAP_deCOOHase_LysA.
DR InterPro; IPR022643; De-COase2_C.
DR InterPro; IPR022644; De-COase2_N.
DR InterPro; IPR022653; De-COase2_pyr-phos_BS.
DR InterPro; IPR000183; Orn/DAP/Arg_de-COase.
DR InterPro; IPR029066; PLP-binding_barrel.
DR PANTHER; PTHR43727; DIAMINOPIMELATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43727:SF2; DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF02784; Orn_Arg_deC_N; 1.
DR Pfam; PF00278; Orn_DAP_Arg_deC; 1.
DR PRINTS; PR01181; DAPDCRBXLASE.
DR PRINTS; PR01179; ODADCRBXLASE.
DR SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
DR PROSITE; PS00878; ODR_DC_2_1; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR600183-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000004830}.
FT DOMAIN 45..294
FT /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02784"
FT DOMAIN 296..390
FT /note="Orn/DAP/Arg decarboxylase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00278"
FT ACT_SITE 363
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
FT MOD_RES 70
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
SQ SEQUENCE 454 AA; 50119 MW; DA26DA9B520E124A CRC64;
MEDHQQNQED LDRAYAAKQP FATKEQIESL VQHYPTPFHL YDEAGIRKNM EAIRDAFAWN
PGFKEYFAVK ANPNPRLISI LREYGCGADC SSDTELMIAR SLGITGSDIM FSSNNTPAAD
FALASELGAT INFDDITHID FFERTAGAVP KTVSCRFNPG GLFQLANGIM DNPGDSKYGM
TEEQLFDAYR MLKEKGAETF GLHAFLASNT VTNEYYPALA RILFDLARRL QEETGCRVGF
INLSGGVGIP YRPEQQANDI RAIGEGVRRA YEEILVPAGM DDVAVFAEMG RFVMGPYGCL
VTRAIHTKDI YKHYVGVDAN ACNLIRPAMY GAYHHVTVVG QPGGPDKTHA SADAVYDIVG
NLCENNDKFA VDRAMPHIDI GDLLVIHDTG AHGHSMGYNY NGRLRSAEVL LRSDGTDELI
RRAERPDDYF ATLDVLPEGR ALINACRDCG GKDE
//
