ID G2M740_HELPX Unreviewed; 470 AA.
AC G2M740;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=HPPN135_00205 {ECO:0000313|EMBL:AEN17755.1};
OS Helicobacter pylori Puno135.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1055529 {ECO:0000313|EMBL:AEN17755.1, ECO:0000313|Proteomes:UP000008533};
RN [1] {ECO:0000313|EMBL:AEN17755.1, ECO:0000313|Proteomes:UP000008533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Puno135 {ECO:0000313|EMBL:AEN17755.1,
RC ECO:0000313|Proteomes:UP000008533};
RA Kersulyte D., Cabrera L., Hooper C.C., Jahuira Arias H., Gilman R.H.,
RA Berg D.E.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR EMBL; CP002982; AEN17755.1; -; Genomic_DNA.
DR RefSeq; WP_000694825.1; NC_017379.1.
DR AlphaFoldDB; G2M740; -.
DR KEGG; heu:HPPN135_00205; -.
DR PATRIC; fig|1055529.4.peg.39; -.
DR HOGENOM; CLU_035527_1_0_7; -.
DR Proteomes; UP000008533; Chromosome.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEN17755.1}.
FT DOMAIN 4..278
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 311..461
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
FT COILED 326..353
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 470 AA; 53209 MW; 79BB7C36CA976F92 CRC64;
MKIKNILLSG GSGKRLWPLS RSLYPKQFLK LFGNESLFEL SFKRNASLVD ETLIVCNEKH
YFLALEEIEN EIKNKSVGFL LESLSKNTAN AIALSALMSE REDLLIVTPS DHLIKDIQAY
ENAIKKAIDL AQKGFLVTFG INIEKPNTEF GYIESPNGLD VKRFIEKPSL EKAIEFQKSG
GFYFNSGMFV FQAGVFLDEL KKHAPIILKG CERAFESLER ASFFEKKIAR LSEKSMQDLE
DVSVDIALMQ QSHKIKMVGL NAKWSDLGNF NALFEEVANE PKENVSLNQT PVFAKESQNN
LVFSHKVSAL LGVENLAIID TKDALLIAHK DKAKDLKALV SEVEANNQEL LQTHTKVYRP
WGSYEILHES GCYKVKILEV KPNARLSLQK HFHRSEHWVV ISGMASVELD HQSFELQANE
STYIPKNTLH RLANYGKIPL TIIEVQVGEY VGEDDIVRVD DDFNRQNQGK
//
