ID   G2M929_HELPX            Unreviewed;       949 AA.
AC   G2M929;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=HPPN135_07880 {ECO:0000313|EMBL:AEN19235.1};
OS   Helicobacter pylori Puno135.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1055529 {ECO:0000313|EMBL:AEN19235.1, ECO:0000313|Proteomes:UP000008533};
RN   [1] {ECO:0000313|EMBL:AEN19235.1, ECO:0000313|Proteomes:UP000008533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Puno135 {ECO:0000313|EMBL:AEN19235.1,
RC   ECO:0000313|Proteomes:UP000008533};
RA   Kersulyte D., Cabrera L., Hooper C.C., Jahuira Arias H., Gilman R.H.,
RA   Berg D.E.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP002982; AEN19235.1; -; Genomic_DNA.
DR   RefSeq; WP_000380028.1; NC_017379.1.
DR   AlphaFoldDB; G2M929; -.
DR   KEGG; heu:HPPN135_07880; -.
DR   PATRIC; fig|1055529.4.peg.1567; -.
DR   HOGENOM; CLU_010638_1_0_7; -.
DR   Proteomes; UP000008533; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          1..426
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   COILED          60..87
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          262..289
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         12..19
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   949 AA;  109694 MW;  61127106E3DD3D04 CRC64;
     MDTKRQCMAL KASAGSGKTF ALSVRFLALL FKGANPSEIL TLTFTKKATA EMKERILDYL
     KILQKENLED EKEKEKSQNI LKELEEKYRL NPSLVQNSAQ KIYQRFLNAE IRISTIDAFF
     QSILRKFCWF VGLSANFEVN ENTKAHQQQL NASFLSALNN EQLEELSVFI TQCLSHDNYT
     SDSILERLRF LKNKLYLFDP NKKEPAFDEE GFLEKIRSLN QQIQSVETAS DMAKTAIKCD
     DFRGFLNSSL TWLEKKSEYR YFKKFKDEIP TLESECEEIE SDLKRYYEAR ESALFKKFPK
     FIQLYDKATS KIQALDFDAI KDKVHALLNG YEEMPAEFFY FRLDSKIAHI LIDEFQDTSL
     NDYKILAPFI DEIKAGIGQA KWHRSVFFVG DVKQSIYGFR GSFSSLFESV SKDFYHDNLQ
     FNHRSSPLII NYVNTIFKKA YQNSPTAYLE QKYPKASSNK HARDGYVKVS LVADERELLL
     EQILQEAKNL LEHRIDPKDI TLLCATNDDA LEIKNYLQEN LSEIRPSTES SAKLSQFVES
     KIIKNALKYA LAEEPYKPFY KHSVLKLAGY LHDDAIALAG FNPKKESVAG FVWKVMELFE
     LYGECAQICL ELAVGCEDAN EFLEKLEAKE IASFNAKGAQ IMTIHKSKGM QFPYVIVCER
     LGKPKTNSSN QFLEEYDGTE LTRLYYRMKN REVVDKDYAR ALDKEEAAKD HEETNVYYVA
     FTRAELGLIV VAKDKDQKKD KKESKNKKMR EQLDLVPLEE GEITPVISPQ KEPLITSALI
     KPHAYGEQVQ EIEEEPSDYE KNNDQEAINF GIALHKGLEY QYAYNIPKKS VLEYLNYHHG
     FYGLDYQALE ESLELFENDA EIQTLFKNHA LKGEAAFLFE GVVSRIDVLL WDRGQNLCVL
     DYKSSQNYQQ SHKAQVSHYA AFLKTQAPHF KIQAGIIYAH KRLLEKLWV
//