ID G2NMH4_STREK Unreviewed; 399 AA.
AC G2NMH4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=ROK family protein {ECO:0000313|EMBL:AEN13055.1};
GN ORFNames=SACTE_5239 {ECO:0000313|EMBL:AEN13055.1};
OS Streptomyces sp. (strain SirexAA-E / ActE).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=862751 {ECO:0000313|EMBL:AEN13055.1, ECO:0000313|Proteomes:UP000001397};
RN [1] {ECO:0000313|EMBL:AEN13055.1, ECO:0000313|Proteomes:UP000001397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SirexAA-E / ActE {ECO:0000313|Proteomes:UP000001397};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Davenport K., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Adams A., Raffa K.,
RA Adams S., Book A., Currie C., Woyke T.;
RT "Complete sequence of Streptomyces sp. SirexAA-E.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEN13055.1, ECO:0000313|Proteomes:UP000001397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SirexAA-E / ActE {ECO:0000313|Proteomes:UP000001397};
RX PubMed=24710170; DOI=10.1371/journal.pone.0094166;
RA Takasuka T.E., Acheson J.F., Bianchetti C.M., Prom B.M., Bergeman L.F.,
RA Book A.J., Currie C.R., Fox B.G.;
RT "Biochemical properties and atomic resolution structure of a
RT proteolytically processed beta-mannanase from cellulolytic Streptomyces sp.
RT SirexAA-E.";
RL PLoS ONE 9:e94166-E94166(2014).
CC -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family.
CC {ECO:0000256|ARBA:ARBA00006479}.
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DR EMBL; CP002993; AEN13055.1; -; Genomic_DNA.
DR RefSeq; WP_014049005.1; NC_015953.1.
DR AlphaFoldDB; G2NMH4; -.
DR STRING; 862751.SACTE_5239; -.
DR KEGG; ssx:SACTE_5239; -.
DR PATRIC; fig|862751.12.peg.5442; -.
DR eggNOG; COG1846; Bacteria.
DR eggNOG; COG1940; Bacteria.
DR HOGENOM; CLU_036604_13_3_11; -.
DR OrthoDB; 3189808at2; -.
DR Proteomes; UP000001397; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR000600; ROK.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR Pfam; PF12802; MarR_2; 1.
DR Pfam; PF00480; ROK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01125; ROK; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001397}.
FT DOMAIN 18..68
FT /note="HTH marR-type"
FT /evidence="ECO:0000259|Pfam:PF12802"
SQ SEQUENCE 399 AA; 40811 MW; B4C20F66907907EA CRC64;
METPGSQTSL HRANLERVVR AVRMAGSLTQ AEIARSTGLS AATVSNIVRE LKEGGTVEVT
PTSAGGRRAR SVSLSGDAGI VIGVDFGHTH LRVAIGNLAH QVLAEESEPL DVDASSAQGF
GRAEQLVNRL IETTGIAPGK VIGVGLGVPG PIDVESGTLG STSILPGWTG INPGQELAGR
LGVPVYVDND ANLGALGELV WGAGRGVKDL AYIKVASGVG AGLVIDGHIY RGPGGTAGEI
GHITLDESGP VCRCGNRGCL ETFTAARYVL PLLRPSHGPD LTMDRVVQLA REGDPGCRRV
IGDVGRYIGS GVANLCNLLN PSRVVLGGSL AEAGELVLAP IRDSVSRYAI PSAARQLSVL
PGALGGRAEV LGALALVLSE MGDSTLLEST LPTASPVFT
//
