ID G2T0H6_ROSHA Unreviewed; 2502 AA.
AC G2T0H6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=DEAD-like helicase {ECO:0000313|EMBL:AEN95508.1};
GN OrderedLocusNames=RHOM_01930 {ECO:0000313|EMBL:AEN95508.1};
OS Roseburia hominis (strain DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=585394 {ECO:0000313|EMBL:AEN95508.1, ECO:0000313|Proteomes:UP000008178};
RN [1] {ECO:0000313|EMBL:AEN95508.1, ECO:0000313|Proteomes:UP000008178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183
RC {ECO:0000313|Proteomes:UP000008178};
RX PubMed=26543119; DOI=10.1128/genomeA.01286-15;
RA Travis A.J., Kelly D., Flint H.J., Aminov R.I.;
RT "Complete genome sequence of the human gut symbiont Roseburia hominis.";
RL Genome Announc. 3:E0128615-E0128615(2015).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003040; AEN95508.1; -; Genomic_DNA.
DR STRING; 585394.RHOM_01930; -.
DR KEGG; rho:RHOM_01930; -.
DR eggNOG; COG0553; Bacteria.
DR eggNOG; COG0827; Bacteria.
DR eggNOG; COG4646; Bacteria.
DR HOGENOM; CLU_000181_0_0_9; -.
DR Proteomes; UP000008178; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR41313:SF1; DNA METHYLASE ADENINE-SPECIFIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:AEN95508.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:AEN95508.1};
KW Hydrolase {ECO:0000313|EMBL:AEN95508.1};
KW Nucleotide-binding {ECO:0000313|EMBL:AEN95508.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008178}.
FT DOMAIN 1645..1894
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 2075..2230
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 2462..2502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2404..2431
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2486..2502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2502 AA; 283450 MW; E3AB06D34AEC088D CRC64;
MVAAFEKQKT TAEIAEILKT LYHGGNGLGS VSAWYAEDGI HLSHGKSVRY DRSAQVISWE
SAAERIGELL ESGQFASNVE LAEAAGYERS LLSEKLWYLY HDFSEEAREA GYLSCLSEIK
GNGFPEETRR LMEQLSEPAF RQTLKEEYAA FLTAYQQDRD LLRFHYHRPR EIWENLKDLD
LPRRTFSSEL SQVPTVQHFI TEDEIDAAMT GGSSFAGGKG RIYAFFMANH TDKEKVRFLK
DEYGIGGRSH ALSGATHSGE DHDGKGLHYK KQDCPDVHLN WEKVAKRITS LVQKERYLTE
QEQAQYDKIQ SEQELAEEDA IQVQQPEMEE ETPKPTLGEQ FEQYKPVVTV AISEDTAYRN
ACGHSDRENA VIEGNAAVRR AVLGSKDMEL IRLYSDVPEF RQRLHREVID ETYPKLHELL
RPLSQEDIDT ALCAWNGNIE SKHAVVRYMK DHAREKDTAA WLAQEYRGSN SNSLFVVRAG
SPEETQLPWP KVQRRLAQLI QEERFYTEEE QDRFDDIDPI AIREALEERG IVNGQVADPE
KLDNDSFIQQ VMSDVEQIAA AETKQTSEVA ISDEEYDAVR RPTPQRTSYD PAAPVYAVGD
TVYIEDDAYQ ITELREDTVQ LLPTGMVYPI YRAERKEQFE QLLRADRRNA YYTEFLPTDP
DKADQDLRDV LAHGLMDEAD KKQISTLLQS GRSNSEIAYW LSRAYSGEIE TLNLETGDIA
DYRTTAQGIE LEVMDAEERR LAMLYFRWDE VAPLLRGMYA RQQDGFGQEQ SQPATESPTF
HSETMAVYPG DKNNLPYDVV VERLHIEEPE PPAPVTEPEK TFEEVLDEHP VSIQVNGQWQ
TFPNAKAAEE ASYEEYKANL RRNAKNFRIT DEHLGEGGPK AKFQANVNAI RLLKELEAAG
QQASPEQQEV LSRYVGWGGL SDAFDPEKPA WALEYAQLKE LLTPEEYAAA RSSTLNAHYT
SPTVIQAIYE AVDRMGFETG NILEPSMGVG NFFGMLPEKM RNSRLYGVEL DPVSGRIAKQ
LYPKADITVG GFETTDRRDF FDLAIGNVPF GQYQVNDKAY NKLNFSIHNY FFAKALDQVR
PGGVVAFVTS RYTMDAKDST VRRYLAQRAE MLGAIRLPND AFKKNAGAEV VSDIIFLQKR
DRPLDIVPEW TQTGQTEDGF AINRYFIDHS EMVLGRQEPV STAHGMDYTV NPIEGLELSD
QLHDAVKYIH GTYQEAELPE LGEGEAIDTS IPADPNVKNY SYAIVDGQVY YRENSRMVRP
DLNATAEARV KGLVGLRDCV QELIDLQMDA AVPDSTIREK QAELNSLYDS FSSKYGLIND
RANRLAYADD SSYYLLCALE VIDEDGKLER KADMFTKRTI KPHQAVAVVD TASEALAVSI
SEKACVDMGY MSQLTGKTKE ELAGELQGVI FRVPGQLEKD GTPHYVTADE YLSGNVRRKL
RQAQRAAQQD PVYAVNVEAL TAAQPKDLDA SEIEVRLGAT WIDKEYIQQF MYETFNTPFY
LQRSIGVNYS SFTAEWQIKG KSSVSYNDVA AYTTYGTSRA NAYKILEDSL NLRDVRIYDT
IEDADGKERR VLNAKETTLA AQKQQAIREA FRDWIWRDPE RRQTLVRQYN EEMNSTRPRE
YDGSHITFGG MNPAITLREH QKSAIAHVLY GGNTLLAHEV GAGKTFEMVA ASMEAKRLGL
CQKSLFVVPN HLTEQWASEF LRLYPSANIL VTTKKDFETH NRKKFCARIA TGDYDAIIMG
HSQFERIPIS RERQERLLYE QIDEITEGIA EVQASGGERF TVKQLERTRK SLEARLEKLQ
AEGRKDDVVT FEQLGVDRLF VDEAHNYKNL FLYTKMRNVA GLSTSDAQKS SDMFAKCRYM
DEITGNRGVI FATGTPVSNS MTELYTMQRY LQYERLQELN MTHFDCWASR FGETVTALEL
APEGTGYRAR TRFSKFFNLP ELMNLFKEVA DIKTADQLNL PTPEVEYHNI VAQPTEHQQE
MVKTLSERAS LVHSGTVDPS QDNMLKITSD GRKLGLDQRI VNQMLPDEPG TKVNQCVDNI
MQIWRDGKAD KLTQLVFCDI STPQAKAPAS KAAKTLDNPL LHALEGAVPL PEQEPAFTVY
DDIRQKLIAQ GMPADQIAFI HEANTEVRKK ELFSKVRTGQ VRVLLGSTAK MGAGTNVQDR
LVALHDLDCP WRPGDLAQRK GRIERQGNQN PLVHVYRYVT EGTFDAYLWQ TVENKQKFIS
QIMTSKSPVR SCDDVDETAL SFAEIKALCA GDPRIKERMD LDVEVSRLKL MKADHQSKQY
RLEDQLLKYF PEEIEKHKGF IKGFESDLEV LAAHPHPEDG FAGMEIRGDL LTDKENAGAA
LLDACKEVKT SDPVQIGSYR GYAISVEFSA WKQEYTLLLK GQMTHRATLG IDPRGNLTRI
DNALAQMPQR LEAAKAQLDN LYQQQAAAKE EVGKPFLYEE ELRSKNARLV ELDTLLNIDG
KGHAQPETVV AKSARPSVLD SLKRPATPRS TDKKPKQHEE VR
//
