ID G2T286_ROSHA Unreviewed; 334 AA.
AC G2T286;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=LacI family transcriptional regulator {ECO:0000313|EMBL:AEN96031.1};
GN OrderedLocusNames=RHOM_04545 {ECO:0000313|EMBL:AEN96031.1};
OS Roseburia hominis (strain DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=585394 {ECO:0000313|EMBL:AEN96031.1, ECO:0000313|Proteomes:UP000008178};
RN [1] {ECO:0000313|EMBL:AEN96031.1, ECO:0000313|Proteomes:UP000008178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16839 / JCM 17582 / NCIMB 14029 / A2-183
RC {ECO:0000313|Proteomes:UP000008178};
RX PubMed=26543119; DOI=10.1128/genomeA.01286-15;
RA Travis A.J., Kelly D., Flint H.J., Aminov R.I.;
RT "Complete genome sequence of the human gut symbiont Roseburia hominis.";
RL Genome Announc. 3:E0128615-E0128615(2015).
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DR EMBL; CP003040; AEN96031.1; -; Genomic_DNA.
DR RefSeq; WP_014079076.1; NC_015977.1.
DR AlphaFoldDB; G2T286; -.
DR STRING; 585394.RHOM_04545; -.
DR GeneID; 77458548; -.
DR KEGG; rho:RHOM_04545; -.
DR eggNOG; COG1609; Bacteria.
DR HOGENOM; CLU_037628_6_2_9; -.
DR OrthoDB; 9789891at2; -.
DR BioCyc; RHOM585394:G1H02-923-MONOMER; -.
DR Proteomes; UP000008178; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06284; PBP1_LacI-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR PANTHER; PTHR30146:SF109; TRANSCRIPTIONAL REGULATOR LACI_GALR-LIKE SENSOR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000008178};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 6..48
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 334 AA; 37080 MW; 97F72F87CA932D4C CRC64;
MKKDKITVAD IAKKAGVSPA TVSRVLRHRE LVKSETIQQV ENAMSALGCL LEKGTIAAAT
EQPLIILNVP ELDNVFYLKV IDGALVSAKA HGYRLLINDS PLDRSSIYSF INLLKQVHAA
GVILLNHVSK EQLDMIHSVV PLVQCSEYNE HADYPYVSID DYSAATSAAE YIVSCNCNKI
AMINGPMSFK YAVKRQEGFL DTLRKKDISV RPDWIVSLPE VNYQMAYSAV CRLLNNEIRP
NAFFVISDVF AAAVIRAAKR FDLRIPEDII VVGFDNLDIS IMTCPTITTV NQPSFQLGYS
ACELLLDSIN HPDMFPKSLI LDTELIIRES SAKI
//
