ID G2WE13_YEASK Unreviewed; 749 AA.
AC G2WE13;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Spindle assembly checkpoint component MAD1 {ECO:0000256|ARBA:ARBA00022019};
DE AltName: Full=Mitotic arrest deficient protein 1 {ECO:0000256|ARBA:ARBA00032890};
GN Name=K7_MAD1 {ECO:0000313|EMBL:GAA23306.1};
GN ORFNames=SYK7_025721 {ECO:0000313|EMBL:GAA23306.1};
OS Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's
OS yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=721032 {ECO:0000313|EMBL:GAA23306.1, ECO:0000313|Proteomes:UP000001608};
RN [1] {ECO:0000313|EMBL:GAA23306.1, ECO:0000313|Proteomes:UP000001608}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kyokai no. 7 / NBRC 101557 {ECO:0000313|Proteomes:UP000001608};
RX PubMed=21900213; DOI=10.1093/dnares/dsr029;
RA Akao T., Yashiro I., Hosoyama A., Kitagaki H., Horikawa H., Watanabe D.,
RA Akada R., Ando Y., Harashima S., Inoue T., Inoue Y., Kajiwara S.,
RA Kitamoto K., Kitamoto N., Kobayashi O., Kuhara S., Masubuchi T.,
RA Mizoguchi H., Nakao Y., Nakazato A., Namise M., Oba T., Ogata T., Ohta A.,
RA Sato M., Shibasaki S., Takatsume Y., Tanimoto S., Tsuboi H., Nishimura A.,
RA Yoda K., Ishikawa T., Iwashita K., Fujita N., Shimoi H.;
RT "Whole-genome sequencing of sake yeast Saccharomyces cerevisiae Kyokai no.
RT 7.";
RL DNA Res. 18:423-434(2011).
CC -!- SIMILARITY: Belongs to the MAD1 family.
CC {ECO:0000256|ARBA:ARBA00008029}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DG000043; GAA23306.1; -; Genomic_DNA.
DR AlphaFoldDB; G2WE13; -.
DR HOGENOM; CLU_026595_0_0_1; -.
DR Proteomes; UP000001608; Chromosome VII.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR Gene3D; 3.30.457.60; -; 1.
DR InterPro; IPR008672; Mad1.
DR PANTHER; PTHR23168:SF0; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1; 1.
DR PANTHER; PTHR23168; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1; 1.
DR Pfam; PF05557; MAD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT REGION 39..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 253..314
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 390..442
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 480..582
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 333..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 87648 MW; 1A88B77A418A994B CRC64;
MDVRATLQCF FSALSGQFTG KKLGLEIYSI QYKMSNSGGS SPFLESPGGS PDVGSTNGQS
NRQIQALQFK LNTLQNEYEI EKLQLQKQTN ILEKKYKATI DELEKALNDT KYLYESNDKL
EQELKSLKER SANSINDKDK CIEELRTTLQ NKDLEMETLR QQYDSKLSKV TNQCDHFKLE
AESSHSLLMK YEKEIKRQSV DIKDLQHQVM EKDDELSSVK ASKMINSHPN YSTEEFNELT
EMNKMIQDQV QYTKELELAN MQQANELKKL KQSQDTSTFW KLENEKLQNK LSQLHVLESQ
YENLQLENID LKSKLTKWEI YNDSDDDDDN NVNNNDNNNN NKNDNNNDNN NDTSNNNNIN
NNNRTKNNIR NNPEEIIRDW KLTKKECLIL TDMNDKLRLD NNNLKLLNDE MALERNQILD
LNKNYENNIV NLKRLNHELE QQKSLSFEEC RLLREQLDGL YSAQNNALLE VENSETHASN
KNVNEDMNNL IDTYKNKTED LTNELKKLND QLLSNSNDVE TQRKKRKLTS DQIGLNYSQR
LNELQLENVS VSRELSKAQT TIQLLQEKLE KLTKLKEKKI RILQLRDGPF IKDQFIKKNK
LRLLEKENAD LLNELKKNNP AVETVPISVY DSLNFELKQF EQEVFKSNKR FSRLKQVFNN
KSLEFIDVVN SLLGFKLEFQ QDGRVKIFSC FKPEKYLIAD LNENTLKSNL DADIEGWDDL
MNLWVEDRGQ LPCFLATITL RLWEQRQAK
//
