ID G3ADS8_9GAMM Unreviewed; 549 AA.
AC G3ADS8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|HAMAP-Rule:MF_00473};
DE Short=GPI {ECO:0000256|HAMAP-Rule:MF_00473};
DE EC=5.3.1.9 {ECO:0000256|HAMAP-Rule:MF_00473};
DE AltName: Full=Phosphoglucose isomerase {ECO:0000256|HAMAP-Rule:MF_00473};
DE Short=PGI {ECO:0000256|HAMAP-Rule:MF_00473};
DE AltName: Full=Phosphohexose isomerase {ECO:0000256|HAMAP-Rule:MF_00473};
DE Short=PHI {ECO:0000256|HAMAP-Rule:MF_00473};
GN Name=pgi {ECO:0000256|HAMAP-Rule:MF_00473};
GN ORFNames=STA_A00390 {ECO:0000313|EMBL:CCB84940.1};
OS Candidatus Steffania adelgidicola str. Klausen-Leopoldsdorf.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Steffania.
OX NCBI_TaxID=994478 {ECO:0000313|EMBL:CCB84940.1};
RN [1] {ECO:0000313|EMBL:CCB84940.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Klausen-Leopoldsdorf {ECO:0000313|EMBL:CCB84940.1};
RX PubMed=21833037; DOI=10.1038/ismej.2011.102;
RA Toenshoff E.R., Penz T., Narzt T., Collingro A., Schmitz-Esser S.,
RA Pfeiffer S., Klepal W., Wagner M., Weinmaier T., Rattei T., Horn M.;
RT "Bacteriocyte-associated gammaproteobacterial symbionts of the Adelges
RT nordmannianae/piceae complex (Hemiptera: Adelgidae).";
RL ISME J. 6:384-396(2012).
CC -!- FUNCTION: Catalyzes the reversible isomerization of glucose-6-phosphate
CC to fructose-6-phosphate. {ECO:0000256|HAMAP-Rule:MF_00473}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC ECO:0000256|HAMAP-Rule:MF_00473, ECO:0000256|RuleBase:RU000612};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000256|HAMAP-Rule:MF_00473}.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|HAMAP-Rule:MF_00473,
CC ECO:0000256|RuleBase:RU000612}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00473}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC ECO:0000256|HAMAP-Rule:MF_00473, ECO:0000256|RuleBase:RU000612}.
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DR EMBL; FR872579; CCB84940.1; -; Genomic_DNA.
DR AlphaFoldDB; G3ADS8; -.
DR UniPathway; UPA00109; UER00181.
DR UniPathway; UPA00138; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR Gene3D; 1.10.1390.10; -; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR023096; G6P_Isomerase_C.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00473};
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432, ECO:0000256|HAMAP-
KW Rule:MF_00473};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|HAMAP-
KW Rule:MF_00473};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00473}.
FT ACT_SITE 355
FT /note="Proton donor"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00473"
FT ACT_SITE 386
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00473"
FT ACT_SITE 514
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00473"
SQ SEQUENCE 549 AA; 62105 MW; 3564B934C39B76A7 CRC64;
MKNINPTHTL AWKVLQQHFD VMKDVKISDL FRQDSERFLS FSATFHDYML VDYSKNRITA
ETMMRLLALA KECGLKDAIA SMFQGEKINF TEDRAVLHIA LRNRSNTPIN VDGKNVMLDV
NTVLGKMKIF CKRVINGEWK GYTGRTITDI VNIGIGGSDL GPYMVTEALR PYKNHLNVHY
VSNIDGTHLA ETIKDLDPAT TLFLVASKTF TTQETMTNAQ SARDWFLKSA FDKKRIACHF
IALSSNAKAV TEFGIDTQNM FEVWDWVGGR YSLWSAIGLS IALSLGFENF EKLLSGAHTM
DQHFSSTPLD KNLPVLLALI SIWYNNFFNM ETEAILPYDQ YMHRLAAYFQ QGNMESNGKC
VDRKGYVVNY QTGPIIWGEP GTNGQHAFYQ LIHQGTKIVP CDFIAAAISH NPLADHQDKL
LSNFFAQTEA LAFGKSRAVV EKECSAVGKL TEEVQAILPF KVFEGNRPSN SILLREMTPH
SLGALIALYE HKIFTQGVIF NIYSFDQWGV ELGKQLANRI LSELVSHELI DTHDSSTNAL
INRYKSWRY
//
