ID G3B2M6_CANTC Unreviewed; 2711 AA.
AC G3B2M6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=CANTEDRAFT_92954 {ECO:0000313|EMBL:EGV64718.1};
OS Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC
OS 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Yamadazyma.
OX NCBI_TaxID=590646 {ECO:0000313|Proteomes:UP000000707};
RN [1] {ECO:0000313|EMBL:EGV64718.1, ECO:0000313|Proteomes:UP000000707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 /
RC NRRL Y-1498 / VKM Y-70 {ECO:0000313|Proteomes:UP000000707};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
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DR EMBL; GL996515; EGV64718.1; -; Genomic_DNA.
DR RefSeq; XP_006685524.1; XM_006685461.1.
DR STRING; 590646.G3B2M6; -.
DR GeneID; 18250241; -.
DR KEGG; cten:CANTEDRAFT_92954; -.
DR eggNOG; KOG1826; Eukaryota.
DR HOGENOM; CLU_000439_0_0_1; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000000707; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000707}.
FT DOMAIN 1356..1541
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 197..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2711 AA; 310666 MW; 39E40775387CE055 CRC64;
MDQPHGRQPL QNDSGYNAQL EFINSLTHRL ESFLPNVTGY SLIEVELNPQ FKITKDLLID
RTKFDLKVYG MDYISICFMK LCNIIESINK DAKEVKLKDR DEKQLSSTLI ILKILRELIE
ECWLSRTALS NFKSDVNLMN FEILTNFSFY YHFTPPKPIN VNYINLIIDI LGSLLSGEVI
KRVLSMIQKR PIDGKGYYNS HSSNSDTPSS VQSIVSGASN QQNPQTQLGH NRGPSLMEDP
VLGSDSPIYS SEHETAKLIQ ELDFNIEICL RFIATSNPLQ YYNYLYNNLF KFSVSNEVVP
PYNLQKYAPL IKYTFYSLEN GYAMANVINK SLESIKNTTW KQIILVFYSH SVRDQAFARP
EDYDAIVESS SEVAAICKSI FDQTCSIFEE FPYAGIASMV QTWVSMLNPS DYREYELKPN
KLKLSFNKRL KFINNLIKNS TNRSNLTCFD SLITLYHLAA RFPSNMSNHP VYIFTMSHLD
ETYEALVKVN LSTFSINLNS PNSDYVKICY DNLIVNFFIA AIMLKPEKYC NLLLNRFQSI
KDSYRDVRII VKVVRGLSEY TLSLKSFNQI MTSISPQLKS LSSNVSRLLS QYYENSISIH
TSSSSASVYS DKASVSSSTQ NNTRKLSFDQ ELSPHSSRIL AHHHSHLQQQ SVSSQQLSSH
PQTISSSSFH DINVDELKFS SASISAAAST GTSKLVANVE DLLADLFAIF KASPQLFFND
ISFMEPEIFY QDEDASRARI LKFVQDNVDS LRVGLQSRSM NNTDDSTLFS STCRLIMSIV
DKQSNMTSNL NIVTSFANYS TCKQIVKSIC DSCLSLSLTD VKFKSNLIFL NEFLEMREEF
NKIVTKSPIV QDPRSHCDET DVGNSVERIL LLSLCTHDIQ FYNIVKDTMK WHLLHVKRIS
THFEHNLADT FEKLVQDDFV FTGFVSLHKR FRNILRESRP TKALYQVWLI IYERWCDLLF
NKIASLNEEN LLFRHFTGFL VSTSGCFLSN EFADGDPVLR SKSEQNISNF FDRCINLLTS
SDLVIRVIIK DALSNESHSA VYQLVSNKLV TVVNKFEENK NIYEESVLFT EQTIMIMTSM
LSIPNEGAVV LTALLPEICV VLIKLINLVE DPVNQLRLKL RFCKLTVTIE TNRKRLLLTG
AYKIRNFYAK STCDWLEQSA FFDELPGPVG NQTGFNYINS YKSSNSSTKS TNKDSELVYL
NVDLATESSK ALALQLEDLL LDIPEGTSEK DVPKYKDLSF ANYFSLFYRI LTKYTMNNSG
NVKSKYKIQA IVDNVLKCIT NILQYDTDIG LQLVFPLGYH DNKKIRALFL SVFAEMLYER
KIIRKKSKDF TEINLLGIGS LTDILTSASV IASNQNHNLY ASSLFGVYGY LHKLDELFEN
LLNEEINNVS RTADIFRRNS TLTKLLAKLA KDDGMDYLTL VLKDFVQEFN DKEINFNVEK
EQDSNSNPDL FMSYLNNLVS LICDSADSMP KSFRYVCSQI YRKVNAKVPD ASLIAVGSFV
FLRFFCPAVI SPESFFEIDV ICHSNKKSLL QLVKVLQNMA NKTLSVLKWK SLNQKMDELM
QIQRKIFKFL QDVSSYDSTE YPFEEITEMP IPELRYVHKF FFTYYKEIKQ NFLLGEFSSD
ELKKRVEQMT LCDDILREVG QPKALLTIQG GDGGGYKNFD PTGTVSSEYT EFMNRMSAKY
ADKAIDVSLI HNAIFHDGTP VVVVNLKTLT LVDFDVNLLV YKLFETASQV WDNKFYFVFD
FTQFSTEMHV LVTYATLLNT YGPSQLFKNC TRIYYFNLPI KNVGTFFNLV KPSNVEDKEA
RARFYTYSHC DSNDIISSLC LSEDTMAITR DKKVEFLNCK VLDSTTQSFY SATIKIGRSF
FLICSDEFIA TNHELCATKG FRPVDIYSLS DITRCEITKS SGATDEFTIY FNSGQSVIVR
SHERSEILRF MYFTTSRLPK PYIDEEDRNF QGDVSNLWFG RLFNIVFQSL LCEDDEVRSS
ASYLFASVGN YFEIEYSISK NHAKDIAYPA NTTDFIVAVS KYLSRKFPEM SYRFFRSFFD
CYDKLPSRHR INAILYLSPW LDNICDYIYL KDEQSGPDRV AGIIRQVCSI SALNKDTISA
INDYIWKKLF AESILTPLLL DEIVTFTMDN RNDDPDWSFI ISVLSPSVEL CGETITRLIT
CINEATNNDS EIAAESKLFE IMILVKICAS LFFDSYIFAQ LYLADVFFIC SLFIDNPSLE
FGGDLQKLVI NTIQSFFNKP DLTEIEEKTV EETLAYFSGQ RAKMLFGLTR EKTTATSDIN
QLYNRAASFE TLCDYLNEFI TVLGSADDRS GWRSRWCSYA MDVAFSNSSL FQFRAILVVG
ILSKSGISDH TATNMLKLMS RTSFNNTLES MTNVLMSAAK IFKGLSKDSV FPSIIIWPEL
YLGMLNYSSL YQVSIQCLLN TLLKNYEQGP GFVDRVFEQR KHLESFIESF EKSHGFHIDK
KNILCYVFFI FTQGLKLSHI KHTSLTCMKQ VFKERYVIEA KDEYEVPSGS LPYLLFIWLS
TNESSFSEYI ATTEYQPSEW LIIHNLNAPK VIIDYLLSDQ VYPTLALYQA AYIYATTTVD
SGFKTRFLIL LNQIFSINPR KGQMIFHIIK SELASTMINS NSTDTVIVVS EIMTQIMSDP
TYSLEEHSNA TDEFLKENGM MIMKSYRFRK LSDLLASDET AKEKIERDNE RLQEMIYRSA
SSYVENEKLE D
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