ID G3B622_CANTC Unreviewed; 573 AA.
AC G3B622;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=ribonuclease III {ECO:0000256|ARBA:ARBA00012177};
DE EC=3.1.26.3 {ECO:0000256|ARBA:ARBA00012177};
GN ORFNames=CANTEDRAFT_94123 {ECO:0000313|EMBL:EGV63359.1};
OS Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC
OS 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Yamadazyma.
OX NCBI_TaxID=590646 {ECO:0000313|Proteomes:UP000000707};
RN [1] {ECO:0000313|EMBL:EGV63359.1, ECO:0000313|Proteomes:UP000000707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 /
RC NRRL Y-1498 / VKM Y-70 {ECO:0000313|Proteomes:UP000000707};
RX PubMed=21788494; DOI=10.1073/pnas.1103039108;
RA Wohlbach D.J., Kuo A., Sato T.K., Potts K.M., Salamov A.A., LaButti K.M.,
RA Sun H., Clum A., Pangilinan J.L., Lindquist E.A., Lucas S., Lapidus A.,
RA Jin M., Gunawan C., Balan V., Dale B.E., Jeffries T.W., Zinkel R.,
RA Barry K.W., Grigoriev I.V., Gasch A.P.;
RT "Comparative genomics of xylose-fermenting fungi for enhanced biofuel
RT production.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:13212-13217(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000109};
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DR EMBL; GL996524; EGV63359.1; -; Genomic_DNA.
DR RefSeq; XP_006687152.1; XM_006687089.1.
DR AlphaFoldDB; G3B622; -.
DR STRING; 590646.G3B622; -.
DR GeneID; 18250363; -.
DR KEGG; cten:CANTEDRAFT_94123; -.
DR eggNOG; KOG1817; Eukaryota.
DR HOGENOM; CLU_026251_1_0_1; -.
DR OrthoDB; 5475137at2759; -.
DR Proteomes; UP000000707; Unassembled WGS sequence.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR CDD; cd19876; DSRM_RNT1p-like; 1.
DR CDD; cd00593; RIBOc; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR040540; RNase_3_N.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR InterPro; IPR044449; Rnt1/Pac1_DSRM_fungi.
DR PANTHER; PTHR11207:SF0; RIBONUCLEASE 3; 1.
DR PANTHER; PTHR11207; RIBONUCLEASE III; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF00636; Ribonuclease_3; 1.
DR Pfam; PF18497; RNase_3_N; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00535; RIBOc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF69065; RNase III domain-like; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000707};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 226..348
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 382..449
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 502..567
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 64249 MW; A216E2781ECD6744 CRC64;
MNKDVYNPIN DSFRTFDASH TPSENESLVD QKRHMTDSAK DEGLPYPKRS GSVNSNSNVD
LSNSSGEGLT GDGSGRPSFG FVDIKKLEHS ARMLQKNIKL IVDEAPNIEY LNQLIKSQRG
SLDSLTYDSL RTNKLVHLAA QVKSLYEEGR LKIFDGILEN DLNKSDLSEI ETPNESPQDR
STAPIIPSSD SENETYVSSV PDIIRNKDEE QFAVGSTDDC PELPLIKDPH LYARVFIHKS
TINNKSYLYQ SELITSHNER LEFLGDSVLN NLATLIIYER YPTAPEGELS KMRSILVNNV
TLAEFSIKYG FDKKLKSNIN DTILRQGKQK IFADIFEAYV GALSMEDNLE SGVLKSWLFK
LYWSRLKVFD EEIRETEEVN KDAKSELYSL VGTAAFHPTY DVITTGDGAS KPFKVSCVMG
DEVLGTAVAP GLKEAGLRAA MVALKNKPML EKYIQLRLNT DKTQSIVSHK QGSPMELETT
TLVDPDIQLP LKAEKDMEFD SDARNKLYAI VSKKFNLVPE YYCEETEDRL FTAELRIDNK
AIAFATDISK KKAMAKAAKL ALDTPAVFWN LHS
//
