ID G3D188_SIV Unreviewed; 833 AA.
AC G3D188;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ADM81993.1};
OS Simian immunodeficiency virus (SIV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11723 {ECO:0000313|EMBL:ADM81993.1};
OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ADM81993.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C_DA2D_S_w16_peA3 {ECO:0000313|EMBL:ADM81993.1};
RA Hraber P.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADM81993.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C_DA2D_S_w16_peA3 {ECO:0000313|EMBL:ADM81993.1};
RA Whitney J.B., Hraber P.T., Leudemann C., Giorgi E.E., Daniels M.,
RA Bhattacharya T., Rao S.S., Mascola J.R., Nabel G.J., Korber B.T.,
RA Letvin N.L.;
RT "Genital tract sequestration of SIV during acute infection.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HQ187207; ADM81993.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ADM81993.1};
KW Virion {ECO:0000313|EMBL:ADM81993.1}.
FT TRANSMEM 696..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..528
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 546..740
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT COILED 640..667
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 833
FT /evidence="ECO:0000313|EMBL:ADM81993.1"
SQ SEQUENCE 833 AA; 95979 MW; 21ED42B7FEAB1D9A CRC64;
MGCLGNQLLI AILLLSVYGI YCTQYVTVFY GVPAWRNATI PLFCATKNRD TWGTTQCLPD
NGDYSELALN VTESFDAWEN TVTEQAIEDV WQLFETSIRP CVKLSPLCIT MRCNKSETDK
WGLTKSSTIT TTAPTTPNTT STKSIDMVNE TSSCIVHDNC TGLEQEQMIG CKFNMTGLKR
DKKKEYNETW YSTDLVCEQG NSTDNESRCY MNHCNTSIIQ ESCDKHYWDT IRFRYCAPPG
YALLRCNDTN YSGFMPKCSK VVVSSCTRMM ETQTSTWFGF NGTRAENRTY IYWHGRDNRT
IISLNKYYNL TMKCRRPGNK TVLPVTIMSG LVFHSQPVNE RPNQAWCWFG GNWKDAIKEV
KQTIVKHPRY TGINNTDKIN LTAPRGGDPE VTFMWTNCRG EFLYCKMNWF LNWVEDRDVT
TQRPKERHRR NYVPCHIRQI INTWHKVGKN VYLPPREGDL TCNSTVTSLI ANIDWTDGNQ
TNITMSAEVA ELYRLELGDY KLVEITPIGL APTDVKRYTT GGTSRNKRGV FVLGFLGFLA
TAGSAMGAAS LTLTAQSRTL LAGIVQQQQQ LLDVVKRQQE LLRLTVWGTK NLQTRVTAIE
KYLKDQAQLN AWGCAFRQVC HTTVPWPNAS LTPNWNNDTW QEWERKVDFL EENITALLEE
AQIQQEKNMY ELQKLNSWDV FGNWFDLASW IKYIQYGVYI VVGVILLRIV IYIVQMLTKL
RQGYRPVFSS PPSYFQQTHI QQDPALPTRE GKEGDGGEGG GNSSWPWQIE YIHFLIRQLI
RLLTWLFSNC RTLLSRAYQI LQPILQRLSA VLRRIREVLR TELTYLQYGW SYF
//