ID G3E287_9SAUR Unreviewed; 221 AA.
AC G3E287;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NT-3 {ECO:0000313|EMBL:ADZ46128.1};
OS Epicrates crassus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Henophidia; Boidae; Boinae; Epicrates.
OX NCBI_TaxID=996281 {ECO:0000313|EMBL:ADZ46128.1};
RN [1] {ECO:0000313|EMBL:ADZ46128.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Epcra1 {ECO:0000313|EMBL:ADZ46128.1};
RX PubMed=21912634; DOI=10.1371/journal.pone.0022199;
RA Rivera P.C., Di Cola V., Martinez J.J., Gardenal C.N., Chiaraviglio M.;
RT "Species Delimitation in the Continental Forms of the Genus Epicrates
RT (Serpentes, Boidae) Integrating Phylogenetics and Environmental Niche
RT Models.";
RL PLoS ONE 6:e22199-e22199(2011).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; HQ399530; ADZ46128.1; -; Genomic_DNA.
DR AlphaFoldDB; G3E287; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685,
KW ECO:0000256|RuleBase:RU365037};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 129..219
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADZ46128.1"
FT NON_TER 221
FT /evidence="ECO:0000313|EMBL:ADZ46128.1"
SQ SEQUENCE 221 AA; 24896 MW; B4185E32B0EEDCAA CRC64;
PGFLCGIQST SMDQGILTED SMNSFIRTLI QAGIWKNKVP KQMARTKDGT QTTVKKTEAE
ADAMASQDTR LGFQPIVSVD AELLRQQRRF SSPRVLLSEN TPLEPPPLYL TEEPVVLNRT
SRRKREGKSH RGEYSVCDSE SRWVTDKSSA VDIRGHQVTV LGEIRMGPSP VKQYFYETRC
KQAKPAKSGC RGIDDKHWNS QCKTSQTFVR ALTSENNKTR S
//
