ID G3FHD2_BRABE Unreviewed; 566 AA.
AC G3FHD2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Receptor interacting protein kinase 1a {ECO:0000313|EMBL:AEO79022.1};
OS Branchiostoma belcheri tsingtauense.
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=155462 {ECO:0000313|EMBL:AEO79022.1};
RN [1] {ECO:0000313|EMBL:AEO79022.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21911601; DOI=10.4049/jimmunol.1100816;
RA Li J., Yuan S., Qi L., Huang S., Huang G., Yang M., Xu L., Li Y., Zhang R.,
RA Yu Y., Chen S., Xu A.;
RT "Functional Conservation and Innovation of Amphioxus RIP1-Mediated
RT Signaling in Cell Fate Determination.";
RL J. Immunol. 187:3962-3971(2011).
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DR EMBL; JF719909; AEO79022.1; -; mRNA.
DR AlphaFoldDB; G3FHD2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0045087; P:innate immune response; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:UniProt.
DR GO; GO:0031349; P:positive regulation of defense response; IEA:UniProt.
DR GO; GO:0032103; P:positive regulation of response to external stimulus; IEA:UniProt.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01670; Death; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF975; DUAL SPECIFICITY PROTEIN KINASE SPLA-RELATED; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEO79022.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 18..285
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 482..566
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 350..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 566 AA; 62889 MW; 4C38FAF16005C608 CRC64;
MDAARNRFSV ISKDKLKIYD SCLLGSGGFG FVIKAKHVDW SLDVAVKCIC SKQTMTEKQQ
KDLYLEAEKL EAARFKHVVH FYGMCIEPTF YCLIMDLAES GSLKSLLGVD IPWALRWRIA
FETAVGMNYL HNLAPRILHC DLKSENILLD EEYHVKITDF GLSKWKSITG ATSICNQGEV
GGTATHIPPE SWEDVNCKPD TPWDVYSYGI VLWEILTRRQ PFEHAHNSAH IEIAVKREQR
PDVKLIPTEP QECADFSRLM RQCWSQKPDD RPSFKDCVDR IDPIYRNYKK EVSAAIAALQ
SGSSSNNTAG SRSSVSSVQG KLADLKLEDV VRHYTGGAAP QLDEAVPIQV QSAQGAQHQP
TQDTQGGQHQ PTQDTKGGQY QPTQDTQGGQ YQPTQDTQGG QYQAPPAGGA WAGGLPQGAH
NIPGLGAGAN FNLQSCQNVI IGNNNVINVT NVPAQPSSAK RKNTPMPKNS APQVSEPQRQ
VTNKMLQVVS SHMGRDWKKL ARELDMTEPQ IDQIQYDYHH EGLVEITYQM LIKWKQQNGK
QATVGKLAQA FGNIDKGYLA KHLSHL
//
