ID G3GRK4_CRIGR Unreviewed; 385 AA.
AC G3GRK4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Pygopus-like 1 {ECO:0000313|EMBL:EGV99880.1};
GN ORFNames=I79_000153 {ECO:0000313|EMBL:EGV99880.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV99880.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- FUNCTION: Involved in signal transduction through the Wnt pathway.
CC {ECO:0000256|ARBA:ARBA00037400}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH000003; EGV99880.1; -; Genomic_DNA.
DR AlphaFoldDB; G3GRK4; -.
DR STRING; 10029.G3GRK4; -.
DR PaxDb; 10029-XP_007619427-1; -.
DR eggNOG; ENOG502QTIZ; Eukaryota.
DR InParanoid; G3GRK4; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd15635; PHD_PYGO1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23194; PYGOPUS; 1.
DR PANTHER; PTHR23194:SF3; PYGOPUS HOMOLOG 1; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 306..364
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 191..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 41863 MW; E54873F800F4B329 CRC64;
MKTVCVFLYV LLQGPSYPPL SEYAPPPNPN SDHLVAANPF DDNYNTISYK PLPSSNPYLS
PGYPGFGGYS TFRMPPHVPP RMSSPYCGPY SLRNQPHPFP QNPLGMGFNR PHAFNFGPHE
NPNFGNPPYN NVLTQDMNMP GQHFRQSSAE NFSQIPPQNA GQVSNADLAS NFVPGNNSHF
TSPLESNHSF IPPPNAFGQA KAPPSKQDFT QGATKTTNQN SSAHPPHLNM EDTVNQSGVE
LKNVNRNNAV QENSRSGSAE ATNSHANGTQ SKPRQPRGAA DLCTTDKSRK FSLHPGRHGH
SSSDPVYPCG ICTNEVNDDQ DAILCEASCQ KWFHRICTGM TETAYGLLTA EASAVWGCDT
CMADKDVQLM RTREAFGPPA VSGDA
//
