ID G3GS21_CRIGR Unreviewed; 1582 AA.
AC G3GS21;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 5 {ECO:0000313|EMBL:EGV97720.1};
GN ORFNames=I79_000328 {ECO:0000313|EMBL:EGV97720.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97720.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC {ECO:0000256|ARBA:ARBA00009312}.
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DR EMBL; JH000005; EGV97720.1; -; Genomic_DNA.
DR STRING; 10029.G3GS21; -.
DR PaxDb; 10029-XP_007636086-1; -.
DR eggNOG; KOG1729; Eukaryota.
DR eggNOG; KOG3531; Eukaryota.
DR InParanoid; G3GS21; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001377; Ribosomal_eS6.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF13; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF01092; Ribosomal_S6e; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM01405; Ribosomal_S6e; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1009..1203
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1232..1326
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1367..1420
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1483..1581
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 35..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..282
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1582 AA; 174480 MW; B4AAE45240B2D340 CRC64;
MKVNISFPAT GCQKLIKVDD ECKLHTFYEK PMATEVAGEA HGHRNSPKPP VAPKPKVTTS
PSTPTAKFPR SPRPDSFPSP NSMSRGPKPP IAPKPRLAGP SEYGAGVYLN NSLSKCSNGR
LLYQDQGLYD GHHSTLNCSE LETDAEYIMV PRAIQREDAP MDGATGEQGF EEEVQEHDTE
HMGTEGDMAV PDEEAPSRDS EEGMDHTLEG EEDCDPGPER DETPTSPDEG ELNRDNEGGE
EDCDQGPGME EQPMCEEEEE EEEEEKLEEE EKLEEEEKLE EEEEVKEHAC NLDGSGPWDE
EEPFHREVVL THVCSESPEV PCWEPGSPET PGKVKEDNED GSNSTESGEP NQDTGQDTED
ANVGSPENGE VPLDVQEQEV TADSPEVFEE DCGDAAEGGG QVDQEEPLRC DEEAYNRETP
AATLQVGEDP EEGGNPVQGD PAEENCQIIP FESDSMEEDL APTLTESPYE LFPTESTSFC
NDIYSLSESA KGQEPVCGIC TEEAPGTDPS RNQHGSLQDG AGEAPPVPDV VVVPEDEDAM
DDALNSPYVM GVGLLSPGEG TQSDTQAASG TRSGYSTWEE GDSEGGLVPV DRKNIATRAR
PHSGKVAGHV PETVLEETGS EACSSAVGTR DTSEEVKKIG MLPEGKPPES GRALPAKPRA
FTLYPRSFSV EGRESPLSMF REPDGAGLDS HRVRRKEDNL SLPGAIGSSG SFSQRSHLPS
SGTSTPSSVV DIPPPFDLAC ITKKPITKSS PSLLIDGDTL DKASKKKKSS FKRLLELTFR
KKTDNKVHMD MNLSSSRSSS ESSYHGPARV LELDRRSLSN SPQLKCRTGK LRASDSPASL
IFYRDGKRKG VPFSRTVSRV ESFEDRSRPP FLPLPLTKPR SISFPNADTS DYENIPAMNS
DYENIQMPPR RPARAGTFTK LFEEQSRALS TANENDGYVD MSSFNAFESK QQTSEQEAES
AYTEPYKVCP ISAAPREDLT SDEEQGSSEE EDGASRDPSL THKVEGQSRA LVIAQELLSS
EKAYVQMLQH LSLDFHGAVL RALENIEQEG REPLAQEELR QGLQELPAIC DLHQGILENL
EQRLGDCSGE GQQQVADIFL AREQEFEHHA AHILQFDRYL GLLAESCLLS PRLATTVREF
EQSSQGGGQS MKHRMLRVVQ RLFQYQVLLT DYLNNLCPDS AEYDNTQSAL TLISKVTDRA
NESMEQGENL QKLVHIEYSV RGQGDLLQPG REFLKEGTLM RVRGKSRHPR HLFLMNDTLL
YTHPQKDGKY RLKSSLPVAN MKVSRPVMDK VPYALKIETP ETCLTLSASS CAERDEWHYC
LSRALPEDYK TQALAAFHHS VEIRERLGIS LGERLPTLVP VTHAMMCMNC GCDFSLTVRR
HHCHACGKIV CRNCSRNKYP LKCLKNRMAK VCDGCFRELK LRNGPVPGTM RERPVSMSFP
LSSSRFSSGS TFSSVFHSIS PSTFKKQKKV PSALAEVAAS GEGSAISGYL SRCKSGKRRW
KKLWLVIKGK VLYTYLASED KVAMESIPLL GFTIAPEKEA GSNEAGPVFH LYHKKTLFYS
FKAEDSNSAQ RWIEAMEDAS VL
//
