ID G3H0C1_CRIGR Unreviewed; 375 AA.
AC G3H0C1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Hydroxylysine kinase {ECO:0000256|ARBA:ARBA00040505};
DE EC=2.7.1.81 {ECO:0000256|ARBA:ARBA00038873};
GN Name=Hykk {ECO:0000313|Ensembl:ENSCGRP00001017529.1};
GN ORFNames=I79_003576 {ECO:0000313|EMBL:EGW03753.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03753.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW03753.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001017529.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC lysine. {ECO:0000256|ARBA:ARBA00037368}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC ChEBI:CHEBI:58357; EC=2.7.1.81;
CC Evidence={ECO:0000256|ARBA:ARBA00036820};
CC -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC {ECO:0000256|ARBA:ARBA00006219}.
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DR EMBL; JH000090; EGW03753.1; -; Genomic_DNA.
DR RefSeq; XP_003497953.1; XM_003497905.3.
DR RefSeq; XP_007617530.1; XM_007619340.2.
DR STRING; 10029.G3H0C1; -.
DR PaxDb; 10029-XP_007616063-1; -.
DR Ensembl; ENSCGRT00001021773.1; ENSCGRP00001017529.1; ENSCGRG00001017551.1.
DR GeneID; 100756410; -.
DR CTD; 123688; -.
DR eggNOG; ENOG502QT7T; Eukaryota.
DR GeneTree; ENSGT00390000011314; -.
DR OMA; AAHSCQL; -.
DR OrthoDB; 5398335at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR GO; GO:0047992; F:hydroxylysine kinase activity; IEA:Ensembl.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR21064:SF1; HYDROXYLYSINE KINASE; 1.
DR PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transferase {ECO:0000313|EMBL:EGW03753.1}.
FT DOMAIN 38..283
FT /note="Aminoglycoside phosphotransferase"
FT /evidence="ECO:0000259|Pfam:PF01636"
SQ SEQUENCE 375 AA; 42263 MW; 6A82AA06A7101E42 CRC64;
MSSGDGLPSQ TSNKPTFTEI QASALVESVF GFKVSKIQPL PSYDDQNFHV CISRTKDSTG
DPVEYVLKIS NTESSQTPDL IEMQNHVIMF LRAAGFPTPS VCRTKGDNTI SLMSIDSGSE
IKSYLVRMLT YLPGRPIAEV AISHQQLYEI GRLAAQLDKT LEEFHHPKLN LLHRENFIWN
LKNVPLLEKY IGALSQNRNR EIVEQVIQLF KEEVMTKLSH FRECINHGDL NDHNILVDSK
SASGDAVYQV SGILDFGDMS YGYYVFEVAI TIMYMMIEST NPLQVGGHIL AGFESVIPLT
AVERSALFVL VCSRFSQSLV MAAYSCQLYP DNKEYLMITA KTGWQHLQQL FDMGQKAVEE
IWFETAKSYE SRISV
//
