ID G3H1Q2_CRIGR Unreviewed; 1314 AA.
AC G3H1Q2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Cyclic nucleotide-gated cation channel alpha-3 {ECO:0000313|EMBL:EGW06444.1};
GN ORFNames=I79_004084 {ECO:0000313|EMBL:EGW06444.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW06444.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH000108; EGW06444.1; -; Genomic_DNA.
DR STRING; 10029.G3H1Q2; -.
DR PaxDb; 10029-XP_007615960-1; -.
DR eggNOG; KOG0500; Eukaryota.
DR InParanoid; G3H1Q2; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR032406; CLZ_dom.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR032770; DUF4537.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46785; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B; 1.
DR PANTHER; PTHR46785:SF1; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B; 1.
DR Pfam; PF16526; CLZ; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF15057; DUF4537; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13768; VWA_3; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 792..816
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 930..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..309
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1106..1220
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 758..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1314 AA; 149677 MW; 7D5AFE2728382E5A CRC64;
MIPGAVSVES KRNAEDSWDS QKWLQKYGLK AQKLTFYDVL ADCSFRHSDG VVDIKAKPED
ESVQTSAVGG SWKTVHAKYC RRFIHVPWKN GSMVHVIITK EKFKWYSERI HIALARIQRR
IKWLQDGSRV LFGKVRGDCI YVLIDTSHSM KSKLDLVKNK IIQLIQEQLR YKSKFNFVTF
DGQAIAWREK LTEINEDNLE QAESWIRDIK VGSSTNTLNA LKIAFSDKET QAIYLLTDGR
PDQPPEMVMD HVKLFQNIPI YAISFNYNDK PANKFLKELA SLTGGEFHAY DFACKDPILQ
DIQSAADSMI VSPPDVFKGP WKVSYGKTQK KKSLHAEATK TSLLRSNISK SCNDTKESSN
SNDCAPASLK VNILLINKYL NDKLSERLTR NESQLSDHTS SDMSSENWLQ NHSLVAKKLT
LMDALTATMV PHSATYVPIL NKPVASKVFK EVSPLAHVGS DTNKMILINP QGAELDNYKQ
NVEQAIKSYE KLDAIKPIQY LENKAVLNKA LERLNWPISL KELSMLENEI LVGKMYIQQA
MELQEAAMKN YSSKPLEEQQ KLPGSPAKKI KSRKIDSLKG QKVIARCEEN GFYFPGVVKK
SVSPTHALVE FRYGETKAVP ISFITPIGGA MPCPQLQVGD YVFAKIRTSK GFDFYVPAIV
IALPNQSGSS EKHYTVLKCN NRREFCTRSA LIKISQNKYA LSCSQIKSCP LEKDQPVVSR
LIISLRAWAT RHLHHEDQRP DSFLDRFHGA ELNEVSIRES NAQPNEGGQE PPDRGKGRKK
DAIVVDPSSN IYYRWLTVIA LPVFYNWCLL VCRACFDELQ SEHLKLWLVL DYSADVLYVV
DMLVRARTGF LEQGLMVRDA KRLWKHYTKT LHFNLDILSV IPTDLAYLKL GINYPELRFN
RLLKFSRLFE FFDRTETRTN YPNVFRIGNL VLYILIIIHW NACIYFAISK FIGFGTDSWV
YPNISKPEYG RLSRKYIYSL YWSTLTLTTI GETPPPVKDE EYLFVVIDFL VGVLIFATIV
GNVGSMISNM NASRAEFQAK IDSIKQYMQF RKVTKDLETR VIRWFDYLWA NRKTVDEKEV
LKSLPDKLKA EIAINVHLDT LKKVRIFQDC EAGLLVELVL KLRPAVFSPG DYICRKGDIG
REMYIIKEGK LAVVADDGVT QFVVLSDGSY FGEISILNIK GSKSGNRRTA NIRSIGYSDL
FCLSKDDLME ALTEYPDAKK ALEEKGRQIL MKDNLIDEDL VKAREGTRDI EEKVDYLESS
LDTLQTRFAR LLAEYSASQM KLKQRLSQLE SQMNVRGCGF SPDGQTCGDA AKTE
//