ID G3H2I8_CRIGR Unreviewed; 1237 AA.
AC G3H2I8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Ankyrin repeat and protein kinase domain-containing protein 1 {ECO:0000313|EMBL:EGW03830.1};
GN ORFNames=I79_004401 {ECO:0000313|EMBL:EGW03830.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03830.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH000115; EGW03830.1; -; Genomic_DNA.
DR AlphaFoldDB; G3H2I8; -.
DR STRING; 10029.G3H2I8; -.
DR PaxDb; 10029-XP_007619090-1; -.
DR eggNOG; KOG0192; Eukaryota.
DR InParanoid; G3H2I8; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 5.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR043195; TTC12.
DR PANTHER; PTHR46540; TETRATRICOPEPTIDE REPEAT PROTEIN 12; 1.
DR PANTHER; PTHR46540:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 12; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 11.
DR PROSITE; PS50088; ANK_REPEAT; 11.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Kinase {ECO:0000313|EMBL:EGW03830.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transferase {ECO:0000313|EMBL:EGW03830.1}.
FT REPEAT 101..134
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 502..794
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 842..874
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 875..907
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 908..940
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 941..973
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 974..1006
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1007..1039
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1040..1072
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1073..1105
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1106..1138
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1139..1171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1172..1204
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1218..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1237 AA; 136612 MW; E593FFCB3EF188C8 CRC64;
MLQTALLSEA FLASVEKDAK ERAKRRRESR VLADALKEKG NEAYVKGDYE TAIFYYSEGL
GKLKDMKVLY TNRAQAYIKL GDYEKALVDC EWALKCDERC TKAYFHMGKA HLAMKNYSKS
RECYQKIGEI NPKLQTQVKE SLNQVTLQEK ADLQEKEARE SLDSGKNTAM TTKNLLETLS
KPDQTPLFYA GGIEILTEMM TDCTERTLFR TYGGFSTISD HEVIRKCLFS AGMDAVEEVL
CVAVLKLWQA VCSDNEENQR QLVIHPDMAR LLPSFMTSRI LVIQQQSLAL LLQLTQTENG
RNQVIKQLDM IRLCEALLSF LDFSDKKSNT AIGVLTDLAL EERFQVWLQA NLPGVLPALT
GALVKCEEDV DLFREVTYTL LGLIMNLCLE VPFISEMWAM EMSRKCLALL NSQDGGILTR
AAGVLSRTLS SSPTIVEEAL TAGVVKKMIK FLRMGGQTAS HYAIKTLAVC TNSCHPAREE
VMRLDKKFSI LILLLESEDE ILAGNAALCL GNCMEVPSAA SSLLKTNIIQ ILLKLAGNDS
QRTAVQLNAG IALGKLCTAE PSSEMSCLFE EAVKMERIKF QHIVSIYGVC KQPLGIVMEF
MASGSLEKIL PTHSLSWPLK FRIVHETSLA MNFLHSIKPP LLHLDLKPGN ILLDNNMHVK
ISDFGLSKWM EQSTHMQYIE RSALRGTLSY IPPEMFLENS KTPGPEYDMY SFGIVIWEIL
TQKKPYAENS ANVRLSKNVV STIELACYFL FLYPNPCGAD VTIETDMLLS LLQSPVADPE
CEALVRKVSC KPSLSQPYKV SEEVNQELAH SAGSGDSLKW ILQLSDSKSL VPSDEELYVY
ENKVTPLHFL VAQGSLEQVR LLLSHEVEVD CQTASGYTPL LIATQDQQPD LCALLLAHGA
DANLADEDGW APLHFAAQNG DDHIARLLLD HGALVDTQEH EGWTPLHLAA QNNFENVARL
LVSRQADLNP RENEGKTPLH VAAYFGHIGL VKLLTGHGAE LDAQQRNLRT PLHLAVERGK
VRAIQHLLKS GAFPDALDHG GYSPLHIAVA RGKQLIFKML LRYGASLELP TQQGWTPLHL
ATYKGHVEIV HLLVKSHADL GALGSMHWTP LHLAAFHGEE VVVLALLQGG ANPNATEQSG
WTPLHLAVQK GTFLGIIHLL EHGADVHACN KVGWTPAHLA ALKGNTAILK VLVKAGAQLD
VKDGVGCTPL QLALRSQKQD SDLPGGQGAF ASHSGSF
//
