ID G3H461_CRIGR Unreviewed; 975 AA.
AC G3H461;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=GEM-interacting protein {ECO:0000313|EMBL:EGV97403.1, ECO:0000313|Ensembl:ENSCGRP00001000220.1};
GN Name=Gmip {ECO:0000313|Ensembl:ENSCGRP00001000220.1,
GN ECO:0000313|RefSeq:XP_027250406.1};
GN ORFNames=H671_1g1170 {ECO:0000313|EMBL:ERE91176.1}, I79_005061
GN {ECO:0000313|EMBL:EGV97403.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97403.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV97403.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000030759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17A/GY {ECO:0000313|Proteomes:UP000030759};
RX PubMed=23929341; DOI=10.1038/nbt.2645;
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., Kofler R.,
RA Romand S., Hesse F., Budach W.E., Galosy S., Muller D., Noll T.,
RA Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., Goesmann A.,
RA Helk B., Mott J.E., Puhler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Nat. Biotechnol. 31:694-695(2013).
RN [4] {ECO:0000313|EMBL:ERE91176.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=17A/GY {ECO:0000313|EMBL:ERE91176.1};
RA Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B., Kofler R.,
RA Romand S., Hesse F., Budach W.E., Galosy S., Muller D., Noll T.,
RA Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A., Goesmann A.,
RA Helk B., Mott J.E., Puehler A., Borth N.;
RT "Chinese hamster genome sequenced from sorted chromosomes.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSCGRP00001000220.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:XP_027250406.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027250406.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027250406.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH000137; EGV97403.1; -; Genomic_DNA.
DR EMBL; KE663643; ERE91176.1; -; Genomic_DNA.
DR RefSeq; XP_007617488.1; XM_007619298.1.
DR RefSeq; XP_007635672.1; XM_007637482.2.
DR RefSeq; XP_027250406.1; XM_027394605.2.
DR STRING; 10029.G3H461; -.
DR PaxDb; 10029-XP_007617488-1; -.
DR Ensembl; ENSCGRT00001000244.1; ENSCGRP00001000220.1; ENSCGRG00001000197.1.
DR GeneID; 100758734; -.
DR KEGG; cge:100758734; -.
DR CTD; 51291; -.
DR eggNOG; KOG1453; Eukaryota.
DR GeneTree; ENSGT00950000183110; -.
DR OMA; QYMLGLD; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000030759; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR CDD; cd20816; C1_GMIP-like; 1.
DR CDD; cd04408; RhoGAP_GMIP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF16; GEM-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 85..348
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 495..539
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 556..759
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 230..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..846
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 108150 MW; A1AF440C59DA4C6B CRC64;
MDTTETEVTP TPEGRKRYSD IFQSLDNLEI SLGNVAFDPL AGDLVLREDL EPDKTATATV
VTEESSEASC WSDASSEGPV PLTEEELDLR LIRTKGGVDA ALEYAKAWSR YAKELLAWTD
KRANYELEFA KSVMKIAEAG KVSILQQSQM PLQYIYTLFL EHDLSLGTLA METLAQQKRD
YYQPLAAKRV EIEKWRKEFK EQWLKEQKRM NEAVQVLRRA RLQYIQRKED LRARSQGSPE
DPPPQAAPGS SKQQERRRRS REEAQAKAQE AEALYQTCVR EANMRHQDLE TTKQRIVSHV
RKLVFQGDEV LRRVTLGLFE LRGAQAERGP RAFSALAECC APFEPGQRYR EFVQTLQPGA
PPPPSPAFCF QEFTPVLHSS PQDTKKKFSG PPQARLEEGS SEPGPWEDTS LGSQGMTGPT
PGSDVDSVGG GNESQSLDSP TSSPGAGTRR LVKASSTGTE SSDDFEERDP DLGDGMENGL
GSPFRKWTLS TAAQTHRLRR LRGPAKCREC EAFMVSGTEC EECFLTCHKR CLETLLILCG
HQRLPARMPL FGVDFLQLPR DFPEEVPFVV TRCTAEIEHR ALGLQGIYRV SGSRVRVERL
CQAFENGRAL VELSGNSPHD ITSVLKRFLQ ELTDPVVPFH FYDAFISLAK TLHADPGDDP
GTPSPSPEII RSLKTLLVQL PDSNYSTLRH LVAHLFRVAA RFEENKMSAN NLGIVFGPTL
LRPPDGLRAP SASPMACLLD SGHQAQLVEF LIVNYEQIFG MDELPLASEP LTQDIGLAPA
LLESSPQHPA LLLAQDTQPL TIASDSIPDP RHHSALEKYP KVTPPEIATL QRDEREEKEV
ENTRDGAGEG SSHNPEDLLL GTQSRGHFSR QPVKYSRGGV RPVTHQLSSL ALVAYKLCEE
TPVTVSTVHG GSLRGRSLGP ASASSEGSPL RRNPLPKHFE ITQETARLLS KLDSETVSRA
TSCADTEPEE SEEHL
//
