ID G3H4D1_CRIGR Unreviewed; 1871 AA.
AC G3H4D1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Protein unc-13-like A {ECO:0000313|EMBL:EGV97473.1};
GN ORFNames=I79_005132 {ECO:0000313|EMBL:EGV97473.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97473.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH000137; EGV97473.1; -; Genomic_DNA.
DR STRING; 10029.G3H4D1; -.
DR PaxDb; 10029-XP_007611118-1; -.
DR eggNOG; KOG1011; Eukaryota.
DR InParanoid; G3H4D1; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:UniProt.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF1; PROTEIN UNC-13 HOMOLOG A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..82
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 509..559
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 615..739
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1049..1192
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1301..1456
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT REGION 137..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1841..1871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..333
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1855..1871
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1871 AA; 211549 MW; 68B324F5D7D785E4 CRC64;
MDEKFNTYVT LKVQNVKSTT IAVRGSQPSW EQDFMFEINR LDLGLTVEVW NKGLIWDTMV
GTVWIPLRTI RQSNEEGPGE WLTLDSQAIM ADSEICGTKD PTFHRILLDA HFELPLDIPE
EEARYWAKKL EQLNAMRDQD EYSFQDQPDK PLPVPTSQCY EDPDSAVDDR DSDYRSETSN
SIPPPYYTTS QPNASVHQYS VRPPPLGSRE SYSDSMHSYE EFSEPQALSP TGSSRYASSG
ELSQGSSQLS EDFDPDEHSL QGSELDDERD RDSYHSCHSS VSYHKDSPHW DQDEDLEDEE
LPEEEEEEEE EEEEEELEEE ELEEEEEVPD DLASYAQQED TTVAEPKEFK RISFPPATPQ
KDDKVPAVPA EAPEVAKGIP KPATSEEIAA AESPKVEERS QEDQGGQDAM SRAKSNWLRA
FNKVRMQLQE VSDRQVSLPG GGLIIIDSMP DIRKRKPIPL VSDLSLVQSR KAGITSALAS
STLNNEELKN HVYKKTLQAL IYPISCTTPH NFEVWTATTP TYCYECEGLL WGIARQGMRC
TECGVKCHEK CQDLLNADCL QRAAEKSSKH GAEDRTQNII MVLKDRMKIR ERNKPEIFEL
IQEVFAVTKS AHTQQMKAVK QSVLDGTSKW SAKISITVVC AQGLQAKDKT GSSDPYVTVQ
VGKTKKRTKT IYGNLNPVWE ENFHFECHNS SDRIKVRVWD EDDDIKSRVK QRFKRESDDF
LGQTIIEVRT LSGEMDVWYN LDKRTDKSAV SGAIRLHISV EIKGEEKVAP YHVQYTCLHE
NLFHFVTDVQ NNGVVKIPDA KGDDAWKVYY DETAQEIVDE FAMRYGVESI YQAMTHFACL
SSKYMCPGVP AVMSTLLANI NAYYAHTTAS TNVSASDRFA ASNFGKERFV KLLDQLHNSL
RIDLSMYRNN FPASSPERLQ DLKSTVDLLT SITFFRMKVQ ELQSPPRASQ VVKDCVKACL
NSTYEYIFNN CHELYGREYQ TDPAKKGEVP PEEQGPSIKN LDFWSKLITL IVSIIEEDKN
SYTPCLNQFP QELNVGKISA EVMWSLFAQD MKYAMEEHDK HRLCKSADYM NLHFKVKWLY
NEYVAELPAF KARVPEYPAW FEPFVIQWLD ENEEVSRDFL HGALERDKKD GFQQTSEHAL
FSCSVVDVFS QLNQSFEIIK KLECPDPQIV GHYMRRFAKT ISNVLLQYAD IVSKGFASYC
SKEKEKVPCI LMNNTQQLRV QLEKMFEAMG GKELDAEASG TLKELQVKLN SVLDELSHVF
ATSFQPHIEE CVKQMGDILS QVKGTGNVPA SACSSVAQDA DNVLQPIMDL LDSNLTLFAK
ICEKTVLKRV LKELWKLVMN TMEKTIVLPP LTDQTGTLLR KHGKGLEKGT QMIFNAAKEL
GQLSKLKDHM VREEAKSLTP KQCAVVELAL DTIKQYFHAG GVGLKKTFLE KSPDLQSLRY
ALSLYTQATD LLIKTFVQTQ SAQVVAANDL KWQTSGIFRP FIEVNIVGPQ LSDKKRKFAT
KSKNNSWAPK YNESFQXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXPP SLPKTLLPNS
SPGVPPRQGP R
//