ID G3H812_CRIGR Unreviewed; 428 AA.
AC G3H812;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Interferon-activable protein 203 {ECO:0000313|EMBL:EGV93428.1};
GN ORFNames=I79_006508 {ECO:0000313|EMBL:EGV93428.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV93428.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SIMILARITY: Belongs to the HIN-200 family.
CC {ECO:0000256|ARBA:ARBA00008647}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH000204; EGV93428.1; -; Genomic_DNA.
DR AlphaFoldDB; G3H812; -.
DR STRING; 10029.G3H812; -.
DR eggNOG; ENOG502QTQS; Eukaryota.
DR InParanoid; G3H812; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR CDD; cd08305; Pyrin; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200:SF24; INTERFERON-ACTIVABLE PROTEIN 203-RELATED; 1.
DR PANTHER; PTHR12200; INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER; 1.
DR Pfam; PF02760; HIN; 1.
DR Pfam; PF02758; PYRIN; 2.
DR SUPFAM; SSF159141; HIN-2000 domain-like; 3.
DR PROSITE; PS50824; DAPIN; 2.
DR PROSITE; PS50834; HIN_200; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 1..50
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 94..292
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT DOMAIN 356..428
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT REGION 42..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 48942 MW; B3E1441B5F537197 CRC64;
MQEDYDRFQI ADLMEDKFPN DAGLDTLIEV CQSIEELKGL AKNLKTEKAK VKSQKKEKNK
TAGKQDEPSS SKSLPTGVES NKNKASSKKL GRRNIPKEPS KEQGHQHGPK EVMVLKVTEP
FTYDLIDNKM MFHATVATET EFFRVKVFNT ALKDKFFPKN IIAISDYFGT NGFLEIHSTT
SVSDVNVNQM MVISNALKQR ASATPKIKDL FSLPKGTYMN GEFVVIKKTE RNNFIYYGIE
DDTGKMEVVV YGRLTSIKCE PGNKLRLVCF ELSSSEDTWQ LKSVRHSYMQ VSKRKEGEKS
NIPARRRGRD EPSSSQPMST TNEDLEPESG RSTLNSQKNE RINEIYYWIG DDTGSMEVVV
YGRLTRIRGL EDLDDYQFRT IEGLLRKELR LSKPMQNNYD RIQMADLMED RFPEDAGLIK
TPKNLKTL
//
