ID G3HDK4_CRIGR Unreviewed; 688 AA.
AC G3HDK4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=FAST kinase domain-containing protein 2 {ECO:0000313|EMBL:EGW02341.1, ECO:0000313|RefSeq:XP_027252881.1, ECO:0000313|RefSeq:XP_027252882.1};
DE SubName: Full=FAST kinase domains 2 {ECO:0000313|Ensembl:ENSCGRP00001021632.1};
GN Name=Fastkd2 {ECO:0000313|Ensembl:ENSCGRP00001021632.1,
GN ECO:0000313|RefSeq:XP_027252881.1, ECO:0000313|RefSeq:XP_027252882.1};
GN ORFNames=I79_008587 {ECO:0000313|EMBL:EGW02341.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW02341.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW02341.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001021632.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027252881.1, ECO:0000313|RefSeq:XP_027252882.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027252881.1,
RC ECO:0000313|RefSeq:XP_027252882.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027252881.1,
RC ECO:0000313|RefSeq:XP_027252882.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH000298; EGW02341.1; -; Genomic_DNA.
DR RefSeq; XP_003502168.1; XM_003502120.3.
DR RefSeq; XP_007618987.1; XM_007620797.2.
DR RefSeq; XP_007618988.1; XM_007620798.1.
DR RefSeq; XP_007640909.1; XM_007642719.1.
DR RefSeq; XP_027252881.1; XM_027397080.2.
DR RefSeq; XP_027252882.1; XM_027397081.2.
DR STRING; 10029.G3HDK4; -.
DR PaxDb; 10029-XP_007618987-1; -.
DR Ensembl; ENSCGRT00001025876.1; ENSCGRP00001021632.1; ENSCGRG00001020432.1.
DR GeneID; 100757409; -.
DR KEGG; cge:100757409; -.
DR CTD; 22868; -.
DR eggNOG; ENOG502QVSD; Eukaryota.
DR GeneTree; ENSGT01030000234607; -.
DR OMA; FEIRMDS; -.
DR OrthoDB; 5257459at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:Ensembl.
DR GO; GO:0035770; C:ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:1902775; P:mitochondrial large ribosomal subunit assembly; IEA:Ensembl.
DR GO; GO:0032543; P:mitochondrial translation; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; IEA:Ensembl.
DR GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:Ensembl.
DR InterPro; IPR010622; FAST_Leu-rich.
DR InterPro; IPR013584; RAP.
DR PANTHER; PTHR21228:SF1; FAST KINASE DOMAIN-CONTAINING PROTEIN 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR21228; FAST LEU-RICH DOMAIN-CONTAINING; 1.
DR Pfam; PF06743; FAST_1; 1.
DR Pfam; PF08373; RAP; 1.
DR SMART; SM00952; RAP; 1.
DR PROSITE; PS51286; RAP; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EGW02341.1, ECO:0000313|RefSeq:XP_027252881.1};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Transferase {ECO:0000313|EMBL:EGW02341.1,
KW ECO:0000313|RefSeq:XP_027252881.1}.
FT DOMAIN 616..673
FT /note="RAP"
FT /evidence="ECO:0000259|PROSITE:PS51286"
SQ SEQUENCE 688 AA; 78744 MW; E3F514685E969A80 CRC64;
MSNKAYSLLW NTRQLSTLVP RSRFLRIYPP GFCRPEVIPS KWNPRNCLLN GFGEGLQPSV
RYLFQGVLKS VDCCTQTKGT GCAAVFKLDR VLCPRRLSSD SEHFLVSDGA SDHDLMKINS
HHASSEDVLS KKMRPTPVNH DKLVQECNSL SDVLDTFSKA PKFPSSSYFS AMWTIAKRIS
EDKRRFEIQL MFNHSAFSQL CEQMMRESMI MHYNHLLFSL NAVIKLGVPQ NTLMVQTLLR
VIQERINECD ERCLSILSTV LDTLEPSMNV NALRAGFRIL VDQQVWKIEH IFTLQTVMKF
IGKDTPLALK KKLEMKTLKE LDRFSALNSQ HMFEVLAAMD YRSVVLLNEC SKKVIDNIHG
CPSKVLISIL QSCKALRYQN KDLFKRIADY VATTFEIWKL NQVIFFLLGF ENLGFRPSAL
MDKLMEKVME DPDSLNKKNI VSILHVYSSL NHAHKDQNRE FLEAMASALT VYLHHISSEN
LLSAVYSFCL MNYFPQNLIN QLIKKNIINE LLTSGDTEKN IPKLHVLNTC LKLDESAYYK
AVHIPLPQLP LPLPYPSDRV AEVLSHLLKG EGCFSRNVQL PHNYHIDFEI RMDNNRTQVF
SFSDVDATSG TNMQRVAVLC VPKSAYCLDS NHPRGLLAMK IRHLNTMGFH VILINNWELR
KLRMEDAVAF VKMKIYSDGA FPTTDTTV
//
