ID G3HGF8_CRIGR Unreviewed; 269 AA.
AC G3HGF8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Gem-associated protein 2 {ECO:0000256|PIRNR:PIRNR038038};
GN Name=Gemin2 {ECO:0000313|Ensembl:ENSCGRP00001017768.1,
GN ECO:0000313|RefSeq:XP_027275461.1};
GN ORFNames=I79_009684 {ECO:0000313|EMBL:EGV95226.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV95226.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV95226.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001017768.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027275461.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027275461.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027275461.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: The SMN complex catalyzes the assembly of small nuclear
CC ribonucleoproteins (snRNPs), the building blocks of the spliceosome,
CC and thereby plays an important role in the splicing of cellular pre-
CC mRNAs. {ECO:0000256|PIRNR:PIRNR038038}.
CC -!- SUBUNIT: Part of the core SMN complex. {ECO:0000256|PIRNR:PIRNR038038}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the gemin-2 family.
CC {ECO:0000256|ARBA:ARBA00025758, ECO:0000256|PIRNR:PIRNR038038}.
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DR EMBL; JH000348; EGV95226.1; -; Genomic_DNA.
DR RefSeq; XP_003503037.1; XM_003502989.3.
DR RefSeq; XP_007619480.1; XM_007621290.2.
DR RefSeq; XP_027275461.1; XM_027419660.2.
DR STRING; 10029.G3HGF8; -.
DR PaxDb; 10029-XP_007619480-1; -.
DR Ensembl; ENSCGRT00001022012.1; ENSCGRP00001017768.1; ENSCGRG00001017720.1.
DR GeneID; 100755559; -.
DR KEGG; cge:100755559; -.
DR CTD; 8487; -.
DR eggNOG; ENOG502QPK4; Eukaryota.
DR GeneTree; ENSGT00390000013814; -.
DR OMA; WTLRCEL; -.
DR OrthoDB; 5390889at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0097504; C:Gemini of coiled bodies; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0032797; C:SMN complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000245; P:spliceosomal complex assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 1.20.58.1070; -; 1.
DR InterPro; IPR017364; GEMIN2.
DR InterPro; IPR035426; Gemin2/Brr1.
DR PANTHER; PTHR12794:SF0; GEM-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR12794; GEMIN2; 1.
DR Pfam; PF04938; SIP1; 1.
DR PIRSF; PIRSF038038; SMN_Gemin2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR038038};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR038038};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|PIRNR:PIRNR038038};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
SQ SEQUENCE 269 AA; 30464 MW; CFA70676E392A388 CRC64;
MAWVPAESAV EELMPRLLPV EPCDLTEGFD PSVPPRTPQE YLRRVQIEAA QCPDVVVAQI
DPKKLKRKQS VNISISGCQP APEGYSPTLQ WQQQQVVQFS AVRQSVNKHR NHWKSQQLDS
NVTMPKSEDE EGWKKFCLGE RLYAEGAIGP STNESPGIDY VQIGFPPLLS IVSRMNQATV
TSVLEYLSNW FGERDFTPEL GRWFYALLAC LEKPLLPEAH SLIRQLARRC SEVRLLVGSK
DDERVPALNL LICLVSRYFD QRDLADEPS
//
