ID G3HJZ4_CRIGR Unreviewed; 273 AA.
AC G3HJZ4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Transcription factor SOX-2 {ECO:0000313|EMBL:EGW03628.1};
GN ORFNames=I79_010997 {ECO:0000313|EMBL:EGW03628.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW03628.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH000443; EGW03628.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HJZ4; -.
DR STRING; 10029.G3HJZ4; -.
DR PaxDb; 10029-XP_003504077-1; -.
DR eggNOG; KOG0527; Eukaryota.
DR InParanoid; G3HJZ4; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01388; HMG-box_SoxB; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022097; SOX_fam.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR10270:SF231; TRANSCRIPTION FACTOR SOX-2; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 1..65
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1..65
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 202..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 273 AA; 29797 MW; 56B00AFA3BF3775D CRC64;
MNAFMVWSRG QRRKMAQENP KMHNSEISKR LGAEWKLLSE TEKRPFIDEA KRLRALHMKE
HPDYKYRPRR KTKTLMKKDK YTLPGGLLAP GGNSMASGVG VGAGLGAGVN QRMDSYAHMN
GWSNGSYSMM QEQLGYPQHP GLNAHGAAQM QPMHRYDVSA LQYNSMTSSQ TYMNGSPTYS
MSYSQQGTPG MALGSMGSVV KSEASSSPGV VTSSSHSRAP CQAGDLRDMI SMYLPGAEVP
EPAAPSRLHM AQHYQSGPVP GTAINGTLPL SHM
//
