ID G3HKW0_CRIGR Unreviewed; 697 AA.
AC G3HKW0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Epithelial splicing regulatory protein 2 {ECO:0000313|EMBL:EGW10097.1};
GN ORFNames=I79_011342 {ECO:0000313|EMBL:EGW10097.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW10097.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SIMILARITY: Belongs to the ESRP family.
CC {ECO:0000256|ARBA:ARBA00008866}.
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DR EMBL; JH000471; EGW10097.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HKW0; -.
DR STRING; 10029.G3HKW0; -.
DR PaxDb; 10029-XP_007610096-1; -.
DR eggNOG; KOG1365; Eukaryota.
DR InParanoid; G3HKW0; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12742; RRM3_ESRP1_ESRP2; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR13976:SF30; EPITHELIAL SPLICING REGULATORY PROTEIN 2; 1.
DR PANTHER; PTHR13976; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00023187};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 228..300
FT /note="RRM"
FT /evidence="ECO:0000259|SMART:SM00360"
FT DOMAIN 329..404
FT /note="RRM"
FT /evidence="ECO:0000259|SMART:SM00360"
FT DOMAIN 446..521
FT /note="RRM"
FT /evidence="ECO:0000259|SMART:SM00360"
SQ SEQUENCE 697 AA; 75725 MW; 832332512FBAC2A2 CRC64;
MGKASSPAHS FAEDSLPAGE EAGEIMGSSL ESCWTSPRVW QVVEPRSRQV GTLHKSLVRA
EAAALSPQCR EASGLSADSL ARAESLDKVL QQLVSRDVAL LGGGPHMLCT DGQQLLRQVL
HPEASRKNLV LPDTFFSFYD LRREFHMQHP NTCPARDLTV GTMAQDLGLE TDATEDDFGV
WEVKTMVAVI LHLLEGPNGQ LFSKPEVVKQ KYETGPCSKA DVVDNETVVR ARGLPWQSSD
QDVARFFKGL NIARGGVALC LNAQGRRNGE ALIRFEDSEQ RDLALQRHKH HMGVRYIEVY
KATGEEFVKI AGGTSLEVAR FLSREDQVIL RLRGLPFSAG PTDVLGFLGP ECPVTGGADG
LLFVRHPDGR PTGDAFALFA CEEQAQAALR RHKGMLGKRY IELFRSTAAE VQQVLNRYAT
SPLLPTLTAP LLPIPFPLAG GTGRDCVRLR GLPYTATIED ILSFLGEAAA DIRPHGVHMV
LNQQGRPSGD AFIQMMSSER ALAAAQRCHK KVMKERYVEV VPCSTEEMSR VLMGGSLSRS
GMSPPPCKLP CLSPPTYATF QATPALIPTE TTALYPSSAL LPTARVPATP APLAYYPGPA
TQLYMNYTAY YPSPPVSPTT VGYLTTPPTA LASTPTSMLS QPGALVRMQG VPYTAGMKDL
LSVFQAYQLA PDDYTTLMPI GDPPRTVLQA PKEWVCL
//
