ID G3HP25_CRIGR Unreviewed; 1158 AA.
AC G3HP25;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Nucleolar protein 8 {ECO:0000313|EMBL:EGV99799.1, ECO:0000313|RefSeq:XP_027265730.1};
GN Name=Nol8 {ECO:0000313|RefSeq:XP_027265730.1,
GN ECO:0000313|RefSeq:XP_027265731.1, ECO:0000313|RefSeq:XP_027265732.1,
GN ECO:0000313|RefSeq:XP_027265733.1, ECO:0000313|RefSeq:XP_027265734.1,
GN ECO:0000313|RefSeq:XP_027265735.1};
GN ORFNames=I79_012529 {ECO:0000313|EMBL:EGV99799.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV99799.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV99799.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_027265730.1, ECO:0000313|RefSeq:XP_027265731.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027265730.1,
RC ECO:0000313|RefSeq:XP_027265731.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027265730.1,
RC ECO:0000313|RefSeq:XP_027265731.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; JH000564; EGV99799.1; -; Genomic_DNA.
DR RefSeq; XP_007644044.1; XM_007645854.2.
DR RefSeq; XP_007644045.1; XM_007645855.2.
DR RefSeq; XP_007644046.1; XM_007645856.2.
DR RefSeq; XP_007644047.1; XM_007645857.2.
DR RefSeq; XP_007644048.1; XM_007645858.2.
DR RefSeq; XP_007644049.1; XM_007645859.2.
DR RefSeq; XP_027265730.1; XM_027409929.2.
DR RefSeq; XP_027265731.1; XM_027409930.2.
DR RefSeq; XP_027265732.1; XM_027409931.2.
DR RefSeq; XP_027265733.1; XM_027409932.2.
DR RefSeq; XP_027265734.1; XM_027409933.2.
DR RefSeq; XP_027265735.1; XM_027409934.2.
DR STRING; 10029.G3HP25; -.
DR PaxDb; 10029-XP_007617410-1; -.
DR GeneID; 100757996; -.
DR KEGG; cge:100757996; -.
DR CTD; 55035; -.
DR eggNOG; KOG4365; Eukaryota.
DR InParanoid; G3HP25; -.
DR OrthoDB; 5403746at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP001108280; Chromosome 3.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12226; RRM_NOL8; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR034138; NOP8_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR48029; NUCLEOLAR PROTEIN 8; 1.
DR PANTHER; PTHR48029:SF1; NUCLEOLAR PROTEIN 8; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 8..89
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 246..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1080
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1096
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1158 AA; 130843 MW; 7291883D55B4775F CRC64;
MKPNREMKRL FVGGLGQGIS EADLQNQFSR FGEVSDIEII TRKDDQGNSQ KAFAYVNIKI
TEADLKKCMS ILNKTKWKGG TLQIQLAKES FLHRLAQERE EAKAKKEKST TGNTSLLEKI
GGVDFHMKAV PGTEVPGHKN WVVSKFGRVL PVLHLKSQHK NKIMKYDPSK YCHNLKKIAE
NLTENIPITD LTWELEGGND PMSKKRRGEF SDFYFPPQKM KKVQKSRGPM ESKGSDSSLR
INEVMESNKS TQPVTAHKKA PSSGMPSQSL LVSTSSTPTP DHVIFHTSDF EIIWNKSSMS
DDDIDSEDEL KMMIAKEENL QKTRHSLVNE SENDPFEVVK DDFKSDIHKL HSSAKLGNDC
EYDSSDTDEI IAMKKNIVKV KNSTESSQPE QPISKKSSFK KIEPSNDCVK VQKTKSNKES
ALGHGVKCLN PKFPPDSNVS DCEEESEEDE EYKALMKNCP RVNLTLADLE QLAGSHQKVP
GKDDESDDSQ NINQCIFDTN SKTPRTSYDL HNGRQCICPE DIVASLLEEE DTYSKQKPEE
TTLKPKFQAF KGIGSLYAKE SVDKTLKETV AFNNISEHQS SLKHEDHNRI FIENGSKCAN
GSSSKLTSCQ PAKKVNSPNH IQPPKRQFTV ESQSHEVVSS TSFDKESKNP PSCLLPLKGK
KSLNLGTKSH KIDCDRDTCH LPESRKASEK EGTDTSNITS FEKPRKVCLR EDNQKSTASF
SLSVSNASCV SAKDKHAEDN QKRLAALAVW QKAREVQKKL VHSALANLDG HQENKKTHIV
FASDNESESE ETPTHEQNNC PGKEVVKESV VKASGKLFDS SDDEESDSKE DSTRFNIKPQ
FEGRAGQKLM NLQSHFGSDE RFRMDSRFLE SDSEEEEKEL NENKTNEDEL AAEKKKTLNV
VQSVLNINLN NPTSKGSVTA KKFKDIVHYD PTKHDHAIYE RKQDDNEKES KARRKKKREE
AEKLPEVSQD TYYNIATDLK DIFQNKDTNE KEEDLPWNEG CSGEETGDVS DAANLTSGAE
QTSGFTFSFF DSDTKDIKED TYRIEPVKRG KIVCQEDPRF QDSSSEEEEE EEEKEEEEED
VTKETDHRKP SPGEAFPEKE TTRFFFFTEN DDRLRGSNLF WCGVGSSISR SSWEARTSSL
LLDCRKKHKE AKRKVKAN
//
