ID G3HS11_CRIGR Unreviewed; 909 AA.
AC G3HS11;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Metabotropic glutamate receptor 4 {ECO:0000313|EMBL:EGW01524.1};
GN ORFNames=I79_013636 {ECO:0000313|EMBL:EGW01524.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW01524.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; JH000648; EGW01524.1; -; Genomic_DNA.
DR AlphaFoldDB; G3HS11; -.
DR STRING; 10029.G3HS11; -.
DR PaxDb; 10029-XP_007645000-1; -.
DR eggNOG; KOG1056; Eukaryota.
DR InParanoid; G3HS11; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15452; 7tmC_mGluR4; 1.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001786; GPCR_3_mGluR4.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF23; METABOTROPIC GLUTAMATE RECEPTOR 4; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01054; MTABOTROPC4R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EGW01524.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 584..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 823..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 584..858
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 909 AA; 101393 MW; D96668DBBA25C72B CRC64;
MNSIRIDGDI TLGGLFPVHG RGSEGKACGE LKKEKGIHRL EAMLFALDRI NNDPDLLPNI
TLGARILDTC SRDTHALEQS LTFVQALIEK DGTEVRCGSG GPPIITKPER VVGVIGASGS
SVSIMVANIL RLFKIPQISY ASTAPDLSDN SRYDFFSRVV PSDTYQAQAM VDIVRALKWN
YVSTLASEGS YGESGVEAFI QKSRENGGVC IAQSVKIPRE PKTGEFDKII KRLLETSNAR
AIVIFANEDD IRRVLEAARR ANQTGHFFWM GSDSWGSKSA PVLRLEEVAE GAVTILPKRM
SVRGFDRYFS SRTLDNNRRN IWFAEFWEDN FHCKLSRHAL KKGSHIKKCT RMGTWEDAVP
GSCTADLAHF FESQANEKPC CKEKVKDRER IGQDSAYEQE GKVQFVIDAV YAMGHALHAM
HRDLCPGRVG LCPRMDPVDG TQLLKYIRNV NFSGIAGNPV TFNENGDAPG RYDIYQYQLR
NGSAEYKVIG SWTDHLHLRI ERMQWPGSGQ QLPRSICSLP CQPGERKKTV KGMACCWHCE
PCTGYQYQVD RYTCKTCPYD MRPTENRTSC QPIPIIKLEW GSPWAVLPLF LAVVGIAATL
FVVVTFVRYN DTPIVKASGR ELSYVLLAGI FLCYATTFLM IAEPDLGTCS LRRIFLGLGM
SISYAALLTK TNRIYRIFEQ GKRSVSAPRF ISPASQLAIT FSLISLQLLG ICVWFVVDPS
HSVVDFQDQR TLDPRFARGV LKCDISDLSL ICLLGYSMLL MVTCTVYAIK TRGVPETFNE
AKPIGFTMYT TCIVWLAFIP IFFGTSQSAD KLYIQTTTLT VSVSLSASVS LGMLYMPKVY
IILFHPEQNV PKRKRSLKAV VTAATMTNKF TQKGNFRPNG EAKSELCENL EAPALTTKQT
YVTYTNHAI
//
