ID G3I1S1_CRIGR Unreviewed; 1307 AA.
AC G3I1S1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Murinoglobulin-2 {ECO:0000313|EMBL:EGW04143.1};
DE Flags: Fragment;
GN ORFNames=I79_017340 {ECO:0000313|EMBL:EGW04143.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW04143.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR EMBL; JH001090; EGW04143.1; -; Genomic_DNA.
DR STRING; 10029.G3I1S1; -.
DR InParanoid; G3I1S1; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR PANTHER; PTHR11412:SF133; MURINOGLOBULIN-1-RELATED; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Bait region {ECO:0000256|ARBA:ARBA00023248};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 342..506
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 640..730
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1189..1269
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EGW04143.1"
SQ SEQUENCE 1307 AA; 145813 MW; 2F541E925C5DED6E CRC64;
LISAGLNSFL ARKFMALVPS QLRTETPEKI CLHLYQLSEP VTVKASLQFS WGSRSLFNDL
VVDKDMFHCV SFTLPRVSSS EEKVSLSVHV KGPKHEFSKT NVVMVKNQES VVFVQTDKPM
YKPGQPVKFR VVAMDTNLHP LNELDPKTNR IMQWRDINTE NGLKQLSFSL SSEPILGSYK
IVLQKQSGVK KEHYFTVEEF VLPRFEVRVK VPKAIFIKDE KLNVTVCGVY TYGKPVPGHV
KIRTCHKYQQ YRRQIETQCR ESSYQLDNNG CSTQEEDITE LQLKEKTFED QYLHVNAKIT
EEGTGLEFSG SGSTKIERAA IKLIFVKADS HFKQGIPFIV KVRLVDVKGA PIPNEEVFIK
PRELDYTNVT TTDQHGLAEF SINTTNFDKH SLTIKVMAKD HIIQIGSHTH HTEPGKSPVK
GDFDLNFPVE LSMAPVVSIF VYAILPDGEM IADSAKFEIE KCLRNRVDLS FTPARSLPAS
QAHLQVTASP QSLCGLRAVD QSVLLLRPEA ELSPSWIYNL PELRYTDFIP TLDQLLQDGG
ESCVWTHNKQ KGEVLLHPDE KDVYSYVKDM GLNAFTNLNI KHRKFCIPYD ERHPPISVPA
LAFDGVTNRG DSRTMPKVGH EDPPAADLAT ETIRKYFPET WIWDLVTVNS SGVTEMEVTV
PDTITEWKAG AFCLSNDTGL GLSPVVSLQA FQPFFVELTM PYSVIRGEAF TLKATVINYL
PTCIRVGVLL EDSPDFTAVP VAKDQDSHCL CANGRHTASW LVTPKSLGNV NFSVTAEAQQ
SPEPCGSEVA TVPETGKKDT VVKVLIVEPE GIKKEHTFRS LLCASDAKIS EKVSLKLPTT
VVDDSARAHF SVQGDILSSA IKNTQNLLHM PFGCGEQNMV LFAPNIYVLK YLNETQQLTQ
NIKSKAIGYL TEGYQRELNY KHKDGSYSAF GDQDGQSQGN TWLTAFVLKS FAQARAFIFI
DETHITHAFT WLSQQQQDNG CFRSSGSLFN NAMKGGVKDE VTLSAYITIA LLESSLPDTH
PVVSKALTCL ESSWNTIQQE GNGNFVYTKA LLAYAFALAG NQDKRNEILK SLDNEAIKEE
KSIHWERPQK PMQSERSLYK PQAPSAEVEM NAYVLLTLLT AQPAPTPEDL GVALHIVKWL
TKQQNPHGGF SSTQDTVVAL HALSKYGAVT FAGSQKTPSV TIQSSGTFSR TLQIESSNRL
LLQQVSLPDI PGDYDISVSG EGCVYAQVTN QTLTFSFVIQ QDIPVRNLQP AIVKVYDYYE
TDPCGQRGYI PYWNSAQPMA LLARSDNLEL QKMLLPTSMT FGDELIC
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