ID G3I3F8_CRIGR Unreviewed; 1687 AA.
AC G3I3F8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=PHD and RING finger domain-containing protein 1 {ECO:0000313|EMBL:EGW05534.1, ECO:0000313|RefSeq:XP_027264776.1};
DE SubName: Full=PHD and ring finger domains 1 {ECO:0000313|Ensembl:ENSCGRP00001013932.1};
GN Name=Phrf1 {ECO:0000313|Ensembl:ENSCGRP00001013932.1,
GN ECO:0000313|RefSeq:XP_027264776.1};
GN ORFNames=I79_017965 {ECO:0000313|EMBL:EGW05534.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW05534.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGW05534.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001013932.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027264776.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027264776.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027264776.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JH001184; EGW05534.1; -; Genomic_DNA.
DR RefSeq; XP_007648585.1; XM_007650395.1.
DR RefSeq; XP_027264776.1; XM_027408975.2.
DR STRING; 10029.G3I3F8; -.
DR PaxDb; 10029-XP_007648584-1; -.
DR Ensembl; ENSCGRT00001018169.1; ENSCGRP00001013932.1; ENSCGRG00001014930.1.
DR GeneID; 100775084; -.
DR CTD; 57661; -.
DR eggNOG; KOG0825; Eukaryota.
DR GeneTree; ENSGT00950000183205; -.
DR OrthoDB; 2912044at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 3.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16635; mRING-HC-C3HC3D_PHRF1; 1.
DR CDD; cd15536; PHD_PHRF1; 1.
DR Gene3D; 2.30.30.1150; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047157; PHRF1-like.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR12618; PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12618:SF20; PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 109..150
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 188..238
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1420..1449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1475..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..76
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..386
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1034
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1099
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1687 AA; 184814 MW; 8FD7CC84B558F982 CRC64;
MDDDSLDELV THSPGPDGPP RVDPSDLASD AEESSNGHSG DSEDDTGSEH EDDTDGEETE
GMSEEEDPED RSGSEDSEDG VEMATAAVET QGKLETISAP NSDDDAESCP ICLNAFRDQA
VGTPETCAHY FCLDCIIEWS RNANSCPVDR IIFKCICIRA QFNGKILKKI PVENTRACED
EEAEEEDPTF CEVCGRSDRE DRLLLCDGCD AGYHMECLDP PLQEVPVDEW FCPECAAPGV
APTHDAAPVS DEEVSLLLAD VVPTTSRLRP RVGRTRAIAR TRQSERVRAT VNRNRISSAR
RVQHVPRYLM SSLLDETIEA VATGLSTAVY QRPLTPRVPA KRKRKAGKRK KVLGRKKIRS
RSSVKSKSGG TRAKKRQHRV RKTKGRKLKN EVTSRSRIAR TLGLRRPVHG TSMPSVYKPV
DPTLGLMRAD IGAASLSLFG DPYELDPFDS VPSSNEEPSV DPPSPLSAKR RVLSRSALQS
HQPVARPVAM GLSRRQLPAV APEPSVEEAP VPDLLGSILS GQSLLMMSSA DVVIHRDGSL
SAKRAAPVSL QRNSVTQSRE EFRSRDNLQT GALPSGSTSS GLMGDRQQSS GLSCGDRAAL
RHISGRTVET PVRLDSLVTP RSSQAGNLSN ESRPTVKQNN SPRLNGSNTR ALPLGSASSK
MTTHSNFPSK NRTPGHPQKT DPRKPDFSKL PRIPKIYRDR SDGTQDQAPA SGQTVELPST
CISRLTGREG PGQPGRGRPD NEPSSRGPQE TGSHTGGTRP PAPSSHGSVA PLGPSRGKSI
GSTFESFRIN IPGNTAHCSQ LSSPGFCNTF RPVDSKVQRK ENPSPLFSIK KPKQLKSEIY
DPFDPTGSDS SPPSSSPESL GPGLLPSEIT RTISINSPKA PAFQTVRCVT SYRVESNFGT
EVEPEPQPPG ESVSGMLEFL AKEPAEGASD MEQEGLGEME PTAIQGSTVR TQRPSPPEPW
DDEDGVSCTP FFGSEERTVT CVTVVEPDVP PSPDAPQVTT HRIVELRSPS RSRSTSSSRS
RKKTKKKKVA KEHQRTRSST RSGSRDRTSR SVSPVSEEHT KRHRAKAKSR RSSSDRASSQ
DRAKRRRDRD RDRERRRGPW GHGRCWRKSR SRSGSPGSSS CERHESRRRK RRHSGSRSRG
RDCSPHSSLE RDRRHKHRER SRERMDKKES MTRSRERRRW RSRSPSLEHR SRRPRSREKR
PHSPEKKEAV REVSPAPARQ EEPGQDGNHP AKPVPEVSVL PEVVVADLNP PDVPPVLAEP
VECVPEDLDY GDSVEAGHVF EDFSNEAIFI QLDDMSSPPS PESTDSSPER DFPSNPTVPP
ASLPQDTTLP TIQREALLVH SEDISKPATQ ALTRSDQCLL RQDTVETAAA TLSTPSVVPM
GKDSPLLSGR GCETVQPKDA VAQAPLLRSR TLVKRVTWNL QEAEDNTPTP DRVPRTPLQR
PQRPQEGDWD AEDRALIGVQ QAPFSDLPPP IHVLQETGLP DADPSQPPGA SRAEGLPAVG
TLHSAGGILA QVYSPNMPPP LAQPSSILPY ALVSQPSVQL ILQGTLPLAG CGAAQSLAPV
SNMPATTSEL AIPTTTNNSE ERTATPKSAA EKTKKEEYMK KLHMQERAVE EVKLAIKPFY
QKREVTKEEY KDILRKAVQK ICHSKSGEIN PVKVANLVKA YVDKYRHMRR HKKTEAGEEP
PTQGAEA
//
