ID G3I918_CRIGR Unreviewed; 127 AA.
AC G3I918;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=LY6/PLAUR domain containing 2 {ECO:0000313|Ensembl:ENSCGRP00001011807.1};
DE SubName: Full=Ly6/PLAUR domain-containing protein 2 {ECO:0000313|EMBL:EGV97382.1, ECO:0000313|RefSeq:XP_027260102.1};
GN Name=Lypd2 {ECO:0000313|Ensembl:ENSCGRP00001011807.1,
GN ECO:0000313|RefSeq:XP_027260102.1};
GN ORFNames=I79_020051 {ECO:0000313|EMBL:EGV97382.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV97382.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
RN [2] {ECO:0000313|EMBL:EGV97382.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSCGRP00001011807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:XP_027260102.1}
RP IDENTIFICATION.
RC STRAIN=17A/GY {ECO:0000313|RefSeq:XP_027260102.1};
RC TISSUE=Liver {ECO:0000313|RefSeq:XP_027260102.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
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DR EMBL; JH001556; EGV97382.1; -; Genomic_DNA.
DR RefSeq; XP_003511565.1; XM_003511517.3.
DR RefSeq; XP_007607704.1; XM_007609514.2.
DR RefSeq; XP_027260102.1; XM_027404301.2.
DR STRING; 10029.G3I918; -.
DR PaxDb; 10029-XP_007607704-1; -.
DR Ensembl; ENSCGRT00001016040.1; ENSCGRP00001011807.1; ENSCGRG00001013365.1.
DR GeneID; 100767315; -.
DR KEGG; cge:100767315; -.
DR CTD; 137797; -.
DR eggNOG; ENOG502SG63; Eukaryota.
DR GeneTree; ENSGT00940000162197; -.
DR OMA; RCYVCPE; -.
DR OrthoDB; 3013155at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; CD59; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR035076; Toxin/TOLIP.
DR PANTHER; PTHR16983; UPAR/LY6 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16983:SF16; UPAR_LY6 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00087; Toxin_TOLIP; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022622};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022622};
KW Membrane {ECO:0000256|ARBA:ARBA00022622};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..127
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197668"
FT DOMAIN 23..115
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000259|SMART:SM00134"
SQ SEQUENCE 127 AA; 13421 MW; 03C47DB0BB8814F5 CRC64;
MQGTWMVLLA LVLATCGELA MALQCYTCQD PVSVSNCVAI TTCHINDTMC KTTLYSREIV
FPFLGDSTVT KSCASKCEPS DVDGIGLTRP VSCCNSDLCN MDGAPNLGSP GGLVLAPALI
FILEHLL
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