ID   G3IKI6_CRIGR            Unreviewed;       835 AA.
AC   G3IKI6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Keratin, type II cytoskeletal 1b {ECO:0000313|EMBL:EGW13903.1};
GN   ORFNames=I79_024389 {ECO:0000313|EMBL:EGW13903.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13903.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; JH003628; EGW13903.1; -; Genomic_DNA.
DR   STRING; 10029.G3IKI6; -.
DR   PaxDb; 10029-XP_007614498-1; -.
DR   eggNOG; ENOG502QQIF; Eukaryota.
DR   InParanoid; G3IKI6; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.170; -; 2.
DR   Gene3D; 1.20.5.500; Single helix bin; 2.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF33; KERATIN, TYPE II CYTOSKELETAL 1; 1.
DR   Pfam; PF00038; Filament; 3.
DR   Pfam; PF16208; Keratin_2_head; 2.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 2.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 5.
DR   PROSITE; PS00226; IF_ROD_1; 2.
DR   PROSITE; PS51842; IF_ROD_2; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT   DOMAIN          164..445
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   DOMAIN          523..835
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          219..267
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          343..423
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          578..668
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          734..814
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   835 AA;  93503 MW;  7C4F8202BE18721A CRC64;
     MSHRFSSQSA FSSRSRRAYS SRSSSGFGGG RQAVGSVSRG RCGGGGYGGG FSSRSLYSLG
     GSKSIFGSLV GRSASGFCLG GGAGGFGGGR SFGGGGFGGG GFGSGGRFGG GFGGAGFGAS
     NFGLGGFGPS YPSGGIHEVT INQSLLEPLH LEVDPEIQRV KTQEREQIKT LNNKFASFID
     KVRFLEQQNQ VLQTKWELLQ QVNTSTRTSS LEPVFESYIS QLQRQVDILT SERSRQNLEI
     RSMQDVVEDY KSKYEDEINK RTNAENDFVV MKKELSQMQT HISDTNVILS MDNNRSLDLD
     SIIDAVRVQY ELIAQKSKDE AEALYQTKYQ ELQITAGKHG DDLKNSKMEI AELNRNIQRL
     QAEIASVKKQ IEQMHGSISD AEERGERALQ DAKQKLQDMD EALQQSKEEL ARLLRDYQAM
     LGAKLSLDVE IATYRKLLEG EESRMSGELQ SQVSISVVVV LAXXXXXXXX XXGGGGYGGG
     RFGGGFGPVC PPGGIQEVTI NQSLLQPLNM EVDPEIQKVK SQEREQIKTL NNKFASFIDK
     VRFLEQQNQV LQTKWELLQQ VDTTTRTHNL DPYFETYIAN LRKQVDQLKS DQSRMDSELK
     NMQDMVEDYR NKYEDEINKR TNAENEFVTI KKDVDSAYMN KVELQAKLDN LQQEIDFLTA
     LYREELSQMQ THISETNVIL SMDNNRTLDL DSIISEVKAQ YDDICQRSKA EAETFYQSKY
     EELQITAGKH GDSVKTSKME ISELNRVIQR IRSEIDSVKK QIAHMQQNIS EAEQRGENAL
     KDAQKKLNEL EEAMTQAKEE LARLLRDYQE LMNTKLALDM EIATYRTLLE GEEIR
//