ID G3IKK6_CRIGR Unreviewed; 1276 AA.
AC G3IKK6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=Rho GTPase-activating protein 29 {ECO:0000256|ARBA:ARBA00040783};
DE AltName: Full=Rho-type GTPase-activating protein 29 {ECO:0000256|ARBA:ARBA00042921};
GN ORFNames=I79_024409 {ECO:0000313|EMBL:EGW04207.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW04207.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH003658; EGW04207.1; -; Genomic_DNA.
DR RefSeq; XP_003515062.1; XM_003515014.3.
DR AlphaFoldDB; G3IKK6; -.
DR STRING; 10029.G3IKK6; -.
DR PaxDb; 10029-XP_003515062-1; -.
DR GeneID; 100773090; -.
DR CTD; 9411; -.
DR eggNOG; KOG1453; Eukaryota.
DR InParanoid; G3IKK6; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20816; C1_GMIP-like; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF7; RHO GTPASE-ACTIVATING PROTEIN 29; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 192..462
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 614..659
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 673..888
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 480..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 357..413
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 542..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 143029 MW; 3759751C53761AB6 CRC64;
MIAHKQKKAK KKRVWASGQL SAAITTSEMG LKSVSSNSIF DPEYIKELVN DIRKFSHMLL
YLKEAILSDC FKEAIHIRLD ELLRVLKSIM NKHQNLNSVD LHNAAEALTA KVKAVNFTEV
NEENKNYLFQ EVFSSIETLA FTFGNILTNF LMGDVGNDSV LRLPVSRGSK SFENISVDSV
DLPNEKGNFS PIELDNLLLK NTDSIELALS YAKTWSKYTK NIVSWVEKKL NLELESTRNI
VKLAEATRSS IGIQEFMPLQ SLFTNALLND IHSSNLLQQT IAALQANKFV QPLLGRKNEM
EKQRKEIKEL WKQQQNKLLE TETALKKAKL LCMQRQDEYE KAKSSMFRAE EEQLSSSAGL
AKNLNKQLEK KRRLEEEALQ KVEEANEHYK VCVTNVEERR NDLENTKREI LTQLRTLVFQ
CDLTLKAVTV NLFHMQQLQA ASLANSLQSL CDSAKLYDPG QEYSEFVKAT SSSELEEKVD
GNVNKKITSS PQTPVYGPAD SLEDVARLPD SCSKLEEDRC SNSADMTGPS FVRSWKFGML
SDSESTGGSS ESRSLDSESI SPGDFHRKLP RTPSSGTMSS ADDLDEREPP SPSEAGPNSL
GAFKKTLMSK AALTHKFRKL RSPTKCRDCE GIVMFPGVEC EECLLVCHRK CLENLVIICG
HQKLQGKMHI FGAEFIQVAK KEPDGIPFVL KICASEIENR ALSLQGIYRV CGNKIKTEKL
CQALENGMHL VDISEFSSHD ICDVLKLYLR QLPEPFILFR LYKEFIDLAK EIQHVNEEQE
AKKDSSEDRK HPHVCIEINR ILLRSKDLLR QLPASNFNSL HYLIVHLKRV VDHAEENKMN
SKNLGVIFGP SLIRPRPTTA PVTISSLAEY SNQARLVEFL ITYSQKIFDG SLQPQDVVLA
STAAVAPQLD QGDLSRPLLS PDERDSDRSM KPLFFSSKEQ DSHTADCENK TFESATSLEE
SERKQNALGK CEASLVDKVH LLFDQELESA SPKMEDVCKS PKLLLLKSDR AANSVQRHTP
RTKMRPVSLP VDRLLLLASS PTERNSRNIG NGESDKFGKN PAFEGLHRKD NSNTTCSKVN
GFDPQNLQKS WDKQYERNSF IAKTTMVVPS AHPEKGLTAN IGNSEDHSSR AAQLSNPCTE
PARSARDTSE RRSSDCCPVA TVRAPRTLQP QHWTTFYKPP NPTFSVRGTE EKTAVSLAAV
PSAAVSPVLV RVPQVPVAKP DPDSRVTSAC SVQPSGQPKE NSEEPGLPEG TPACQRPRLK
RMQQFEDLED EIPQFV
//
