ID G3JCH4_CORMM Unreviewed; 1253 AA.
AC G3JCH4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=HECT domain protein {ECO:0000313|EMBL:EGX94635.1};
GN ORFNames=CCM_02906 {ECO:0000313|EMBL:EGX94635.1};
OS Cordyceps militaris (strain CM01) (Caterpillar fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=983644 {ECO:0000313|EMBL:EGX94635.1, ECO:0000313|Proteomes:UP000001610};
RN [1] {ECO:0000313|EMBL:EGX94635.1, ECO:0000313|Proteomes:UP000001610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM01 {ECO:0000313|EMBL:EGX94635.1,
RC ECO:0000313|Proteomes:UP000001610};
RX PubMed=22112802; DOI=10.1186/gb-2011-12-11-r116;
RA Zheng P., Xia Y., Xiao G., Xiong C., Hu X., Zhang S., Zheng H., Huang Y.,
RA Zhou Y., Wang S., Zhao G.P., Liu X., St Leger R.J., Wang C.;
RT "Genome sequence of the insect pathogenic fungus Cordyceps militaris, a
RT valued traditional Chinese medicine.";
RL Genome Biol. 12:RESEARCH116.1-RESEARCH116.21(2011).
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DR EMBL; JH126400; EGX94635.1; -; Genomic_DNA.
DR RefSeq; XP_006668121.1; XM_006668058.1.
DR AlphaFoldDB; G3JCH4; -.
DR STRING; 983644.G3JCH4; -.
DR GeneID; 18164933; -.
DR KEGG; cmt:CCM_02906; -.
DR VEuPathDB; FungiDB:CCM_02906; -.
DR eggNOG; KOG0941; Eukaryota.
DR HOGENOM; CLU_001858_0_0_1; -.
DR InParanoid; G3JCH4; -.
DR OMA; PEDFHTP; -.
DR OrthoDB; 1820836at2759; -.
DR Proteomes; UP000001610; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 6.10.130.10; Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL); 1.
DR InterPro; IPR032353; AZUL.
DR InterPro; IPR042556; AZUL_sf.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF16558; AZUL; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001610};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 903..1253
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1221
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1253 AA; 142292 MW; C8A03440BF4A7B8C CRC64;
MSAQALRLPQ RRPSDSNGHH DGPDDGNDRY DVFDSLWQEA LFARLPPDAP PQLTPFVREI
ENPRRVYAIH RASRRHDFQL LVQLLIHQLR DGCGSDTCHT STCFSCRKRL AGKAPIRRYN
PTSARTLAIY LASQDNPERG ICPSLRRPKD VTPAVNNLVF SKCSVPKSAS QNPSDGDAQR
TVRRTASKSQ SKSRSPSESE DAQVQGKETI DTTLQPESLR DSTEICISER PVARDYRSFA
ATTFGTIAFK MIEWLTPSSL DALSRKICDI RSSSPSNPKP TPVPSPDPQP ITGKEARDRD
HDDTRDASSS PHKSSPHIDP HSIAESRSKR DQPAPKRNSK PALRSKPTVE TTRRKSIEPV
CVTAEADNAT LHRPTRMNGY HPDKLSRRTK SPTTITFKPA FFENVPIPPA VADEVTVTSS
DGEESTKEEM TEPPRPGGNH EHRQKQHSAE EVHDEDLDHA TAMEYPLPQT LSQLNIQIID
FICDVYVDDH TSEDQLHGNI DVGHNYPEPQ ERQGHLVRTP QPRDAACKKL WKDFHEQTLF
SVLSDPAALI LSFSKDGILY DSHSLWYCMV RLMRASPSLV LHSLWLSAAS LFSLPEANVR
KEKGKSRCLS PHQVESVMSI CLHALVALVP VVPDSRLLYD LSRIRSHGLA LSNPSASYRR
PSGLCLKYDD AFSNSLALRL ARRLFLAITI RQKHGNAPLS SLLEQLDLRN TSLERMLKFT
QEERLLHETR VPTLLLDWAR AVLLHEWDGK AQFYKDGTFH GALSFMDTLY KNRNVLLLGE
MQFRVEYFSE RLDAMRVPVQ WTTTNSTDHV GNILDYPYLF QSETLVTYFR SINFACMSRT
FEEASSLKRR MSAIVDPGSL ITNPHHKVVL KDMLRTAASK YLVLDIGRTT VLRDAFDQLW
RRQKRELLRP LKIHLGEDAG EEGFDSGGVQ QEFFRLAVAQ CLDPVYGAFT VDERNHMAWF
KPQPAVEDWK FELMGLLLSL AVYNGLTLPV NFPKAFYRKL LKQPVDQLYH IADGWPELTN
GLTKLLEWDE KDGLIEDIFA RTYEFSVPGV GKDVTIHMLE DKHKEQPGSP VSADTDVPEA
PYVTNENRDE YVNDYIRYLT DYSVRRQFDS FRRGFVACLP EQSLTLLTPS ILQSVVEGVQ
EIDISELRRY ARYVGWDTSH HTVRDFWSIV KRYDDRMKRK LLEFVTASDR VPVSGLKNVQ
FVIQKNGEEN EGGHLPTAYT CYGTLLLPEY RDKEVLRERL GMALENAQGF GFA
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