ID G3JQ90_CORMM Unreviewed; 369 AA.
AC G3JQ90;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:EGX89341.1};
GN ORFNames=CCM_07592 {ECO:0000313|EMBL:EGX89341.1};
OS Cordyceps militaris (strain CM01) (Caterpillar fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=983644 {ECO:0000313|EMBL:EGX89341.1, ECO:0000313|Proteomes:UP000001610};
RN [1] {ECO:0000313|EMBL:EGX89341.1, ECO:0000313|Proteomes:UP000001610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM01 {ECO:0000313|EMBL:EGX89341.1,
RC ECO:0000313|Proteomes:UP000001610};
RX PubMed=22112802; DOI=10.1186/gb-2011-12-11-r116;
RA Zheng P., Xia Y., Xiao G., Xiong C., Hu X., Zhang S., Zheng H., Huang Y.,
RA Zhou Y., Wang S., Zhao G.P., Liu X., St Leger R.J., Wang C.;
RT "Genome sequence of the insect pathogenic fungus Cordyceps militaris, a
RT valued traditional Chinese medicine.";
RL Genome Biol. 12:RESEARCH116.1-RESEARCH116.21(2011).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854}.
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DR EMBL; JH126404; EGX89341.1; -; Genomic_DNA.
DR RefSeq; XP_006672796.1; XM_006672733.1.
DR AlphaFoldDB; G3JQ90; -.
DR STRING; 983644.G3JQ90; -.
DR GeneID; 18169603; -.
DR KEGG; cmt:CCM_07592; -.
DR VEuPathDB; FungiDB:CCM_07592; -.
DR eggNOG; KOG0067; Eukaryota.
DR HOGENOM; CLU_019796_1_3_1; -.
DR InParanoid; G3JQ90; -.
DR OMA; KHGAWQQ; -.
DR OrthoDB; 2900331at2759; -.
DR Proteomes; UP000001610; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001610}.
FT DOMAIN 141..337
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 369 AA; 40061 MW; DE8D93178CE33405 CRC64;
MSLKIAVLDD YQGIAEEYFG ALGGEFEISV QDELVQRLEP FQIIDIHAPS GVIGQDQLGD
NTVDSDLSQT TYIVTTRERT PFPAELVRRL PKLKLLLTNS ARNLALDLDA LQERGVVVAT
VLGLPPVGYT PVVDSTPEHI LTLIMALSKN IAADDASVKT GGWQTGCSTS LSGKTLGLVG
LGRLGVVTAK MLHAALGMQV IAWSPNLTQD KADEQARAAG LAATQPDGRP TFASVSREDL
FSKSDVVSLH LVLSDRSRGL ITAADLHKMK PESFFVNTSR GPLVVERDLL DTLQQGRIRG
AALDVFAIEP LPAESEWRTT AWGKDGRSQV LLTPHTGFVD HATIHGWYKQ QAEEVVRWKN
GQELGKRLV
//
