ID G3N1G4_BOVIN Unreviewed; 1896 AA.
AC G3N1G4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=von Willebrand factor A domain containing 8 {ECO:0000313|Ensembl:ENSBTAP00000055708.2};
GN Name=VWA8 {ECO:0000313|Ensembl:ENSBTAP00000055708.2,
GN ECO:0000313|VGNC:VGNC:36856};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000055708.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000055708.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055708.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000055708.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055708.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSBTAT00000063788.2; ENSBTAP00000055708.2; ENSBTAG00000001133.6.
DR VEuPathDB; HostDB:ENSBTAG00000001133; -.
DR VGNC; VGNC:36856; VWA8.
DR GeneTree; ENSGT00390000006601; -.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000001133; Expressed in semen and 107 other cell types or tissues.
DR ExpressionAtlas; G3N1G4; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039891; VWA8.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR21610; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR21610:SF9; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF07728; AAA_5; 3.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 1705..1887
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1534..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1551
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1896 AA; 213456 MW; 2958C016BEED369F CRC64;
MDRRAWQATV HGVTKSWTRL KRLSTHACVT YTVDASFTSQ GLTWTGDTVN IGDVSYKLKN
PKNPELVPQN YISDSLAQSV IQHLRWIMQK DLLGQDVFLI GPPGPLRRSI AMQYLELTKK
EAEYIALSRD TTETDLKQRR EIRAGTAFYI DQCAVRAATE GRTLILEGLE KAERNVLPVL
NNLLENREMQ LEDGRFLMSA ERYDKLLQDH TKTELDAWKI VRVNENFRVI ALGLPVPRYS
GNPLDPPLRS RFQARDIYYL PFKDQLKLLY SVGANVPTEK VSQLLSFATT LCSQESSTLG
LPDFPLDSLP AAVQILDSFP MMSIQHALQW LYPYTVLLGH EGKMAVQGVL KRFALEDSRR
SVLPEKIVRV ERTTENNVFQ ASVTIRIAEK EVTIKVPAGT RPLSQPCTSD RFIQTLSHKQ
LLAEMMQSHM VKDICLIGGK GCGKTVIAKN FADTLGYNIE PIMLYQDMTA RDLLQQRYTL
PNGDTAWRSS PLVNAALEGK LVLLDGIHRV NAGTLAVLQR LIHDRELSLY DGSRLLREDR
YLRLKEELQM SDEQLQQRSI FPVHPSFRII ALAEPPVIGS TTQQWLGPEF LTMFFFHYMK
PLVKSEEIQV IKEMVPDMPP EALDKLLSFT HKLRETQDPT AQSLAASLST RQLLRISRRL
SQYPNENLHN AVTKACLSRF LPSLARSALE KNLADAAIEI TTDNSPESEL EDYKCELSSG
SLRIGTVSAP IYNAHEKMKV PDVLFYDNIQ HMIVMEDMLK DFLLGEHLLL VGNQGVGKNK
IVDRFLHLLN RPREYIQLHR DTTVQTLTLQ PSVKDGLIVY EDSPLVKAVK LGHVLVVDEA
DKAPTNVTCI LKTLVENGEM ILADGRRIVA NAALVNGREN VVVIHPDFRM IVLANRPGFP
FLGNDFFGTL GDIFSCHAVD NPKPYSELRM LRQYGPNVPE PILQKLVAAF GELRNLADQG
IINYPYSTRE VVNIVKHLQK FPTEGLSSVV RNVFDFDSYN NDMREILTNT LHKYGIPVGA
KPSNVQLAKE LPLPEQTFMG YWTIGQSRNG MQKLLCPAET HHIDVKGPAL IHIQEYPIER
HEGRSQTFTE ECSSWRLPLD EMNLICDVAT AHENEENTLY VVACNPVSLY FMNMTGKSGH
FVDLFDIFPR TASGIWHPFV TVAPLGNPLK GQVVLHEQQS NVILLLDPAS QALRRLILPS
EEFTMKKTSW WNKEEAETYK MCKEFSHKNW LVFYKEKGNT LAVLDVLEGR THTISLPINL
QTVFLVAEDK WLLVESKTNQ KYLLTTPAHI ESKDSGVCQL YVLQEELPSP GFGVMQETDR
SIPHTISSDQ LSSENLSSAV GQKISSPNRI LSDKNSYATV VVGFPDLMSP SEVYSWKRPS
SLSKSRVTDT TFYGGKKKSG TAKQSNCVTL LDTNQIVRIL PPGEVPLQDI YPKDVTPPQT
AGYIEVTDLQ SKRLRYIPIP RSDSLSPYTT WLSTISDTDA LLAEWGRGGV VTVDMGGRVR
LWETGLEHLQ RSLMEWRNMI GEGDRHMQIT IERESGEDVS SPKHGKEDPD NMPHVGGNTW
AGGTGGRDTA GLGGKGGPYR LDAGHTVYQV SEAEKDAVPE EVKRAAREMG QRAFQQRLKE
IQMSEYDAAT YERFSGAVRR QVHSLRIILD NLQAKGKERQ WLRHQATGEL DDAKIIDGLT
GEKAIYKRRG ELEPQMGSPQ QKPKRLRLVV DVSGSMYRFN GVDGRLERSM EAVCMVMEAF
ENYEEKFKYD VAGHSGDGYN IGLVPINKIP KDNKQRLEIL KTMHAHAQFC MSGDHTLEGT
EHAIKEIVKE EADEYFVIVL SDANLSRYGI HPAKFAQILT SSPQVNAFAI FIGSLGDQAA
RLQRTLPAGR SFVAMDTKDI PQILQQIFTS TMLSSV
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