ID   G3N5V7_GASAC            Unreviewed;       833 AA.
AC   G3N5V7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Advillin {ECO:0000313|Ensembl:ENSGACP00000000681.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000681.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000000681.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000000681.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC       {ECO:0000256|ARBA:ARBA00008418}.
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DR   AlphaFoldDB; G3N5V7; -.
DR   STRING; 69293.ENSGACP00000000681; -.
DR   Ensembl; ENSGACT00000000681.1; ENSGACP00000000681.1; ENSGACG00000000528.1.
DR   eggNOG; KOG0443; Eukaryota.
DR   GeneTree; ENSGT00940000159587; -.
DR   InParanoid; G3N5V7; -.
DR   OMA; DPNIWSA; -.
DR   TreeFam; TF313468; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000000528; Expressed in intestinal epithelial cell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   CDD; cd11290; gelsolin_S1_like; 1.
DR   CDD; cd11289; gelsolin_S2_like; 1.
DR   CDD; cd11292; gelsolin_S3_like; 1.
DR   CDD; cd11293; gelsolin_S4_like; 1.
DR   CDD; cd11288; gelsolin_S5_like; 1.
DR   CDD; cd11291; gelsolin_S6_like; 1.
DR   Gene3D; 3.40.20.10; Severin; 6.
DR   Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR036180; Gelsolin-like_dom_sf.
DR   InterPro; IPR007122; Villin/Gelsolin.
DR   InterPro; IPR003128; Villin_headpiece.
DR   InterPro; IPR036886; Villin_headpiece_dom_sf.
DR   PANTHER; PTHR11977:SF33; ADVILLIN; 1.
DR   PANTHER; PTHR11977; VILLIN; 1.
DR   Pfam; PF00626; Gelsolin; 6.
DR   Pfam; PF02209; VHP; 1.
DR   PRINTS; PR00597; GELSOLIN.
DR   SMART; SM00262; GEL; 6.
DR   SMART; SM00153; VHP; 1.
DR   SUPFAM; SSF55753; Actin depolymerizing proteins; 4.
DR   SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 2.
DR   SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR   PROSITE; PS51089; HP; 1.
PE   3: Inferred from homology;
KW   Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          767..833
FT                   /note="HP"
FT                   /evidence="ECO:0000259|PROSITE:PS51089"
FT   REGION          236..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   833 AA;  93901 MW;  1197747628470EF6 CRC64;
     MWSNKAHIAG LFYFTNFFPA QQIFKAVQQK MELVQVPEKS YGNFYEGDCY VLLSTQKTSS
     SLSYDIHYWI GSQSTTDEQG AAALYTIQLD EFLGSTPVQH REVQNHESDA FRGYFKQGLI
     CKKGGVASGM RHIETNCYDV KRLLHVKGRK RVIANEVEMS WKSFNLGDVF LLDIGKTIVQ
     WNGPKSNKQE KLKGMMLAKD IRDRERGGRA EIRVIEGDAE SNSPQTMEIL NSVLGARSSG
     LTDGPPDKTP DQEQKSNLTL HHVTDADGQM TVTEIASRPL VQDLLKHDDC YFLDQGGTKI
     FVWKGKKANK AERQATMARA LEFIKTKNYP NTTNVETVND GAESALFKQL FQRWTVKDQT
     QGLGKVNSKG KVAHIKQEKF DASLMHVMPK VAAQERMVDD GSGQVEVWRI ENLELVPVDP
     QSYGYFYGGD CYLILYSYLV HSKKYYLLYI WQGRHATQDE VAASAFQAVD LDQKYGGEPV
     QVRITMGKEP RHFLAMFKGK MVIFEGGTSR KGSSDPEPPI RFFQVHGSDP YNTKAIEVPA
     LATSLNSNDV FLLKSQSGIH LWCGKGSSGD ERAMAKEVSC VIGQGSEEIV AEGQEPVEFW
     ELLGGKAPYA SEKRLQQMVS DHQARLFECS NKTGCFIVNE VTQFTQDDLI EDDVMLLDTW
     DQVFLWIGKE ANEVERKESV VTSQEYLRTH PGTRDPDTPV LLIKQGFEPP TFTGWFTAWD
     PFKWNGGKSY EDLKKELGEE AAPVNVTTNV SNTKCYPFSE CTSLMSRSVL KSFPPNDLVN
     KINSELPEGV DPTQKEKHLS DSDFNLVFGM TKDNFVSLPG WKQLKMKKEK GMF
//