ID G3N7W7_GASAC Unreviewed; 423 AA.
AC G3N7W7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=von Willebrand factor A domain-containing protein 1 {ECO:0000256|ARBA:ARBA00029542};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000001401.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000001401.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000001401.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR AlphaFoldDB; G3N7W7; -.
DR STRING; 69293.ENSGACP00000001401; -.
DR Ensembl; ENSGACT00000001402.1; ENSGACP00000001401.1; ENSGACG00000001085.1.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000160734; -.
DR InParanoid; G3N7W7; -.
DR OMA; KWETENP; -.
DR TreeFam; TF316402; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000001085; Expressed in pharyngeal gill.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR CDD; cd01450; vWFA_subfamily_ECM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF77; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 16..187
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 192..282
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 312..401
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 399..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 45729 MW; FA20AD5403BB6BFB CRC64;
MQIASPATVL NCCEGDILIL LDSSGSVANH EFLRLLLFAT ELFRPFSLGR GHVRVGLLQV
GTNPHLEFGL DVHSHQEGLQ KALQSISQLQ GDTNTEAALR VAQRVLTETD EKVPKILLWL
TDGVQPGDVD EPMSGMKARG VSVLAVSTVH GNYQVLQRAV TPPLRSHLYS VDIESIDIIT
EDLRDAIIEI IRAERLRVVH LTSHSAVLQW RPVLSTDSGF YELWYNSVRK TDNGIRRILP
GDSTVVQLTD LQPDTTYTAA LRPESNQREF NTLSVTFTTL PGETGCIGSA HATATNLCPH
DPPPTPPPYV LSPAVVSVSD SGPRQIRVSW GPLQGARVQR YTLEYGAIPS GDVRTLILPG
QQNSTVLTGL QPDTQYLVTV SALHVNGKER AMSVRACTQE GPDRPSVDPV GAAGDPGGMA
GPG
//
