ID G3N9F3_GASAC Unreviewed; 229 AA.
AC G3N9F3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000001943.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000001943.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000001943.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC {ECO:0000256|RuleBase:RU241113}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU241113}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the INSIG family.
CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}.
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DR Ensembl; ENSGACT00000001946.1; ENSGACP00000001943.1; ENSGACG00000001491.1.
DR Ensembl; ENSGACT00000001954.1; ENSGACP00000001951.1; ENSGACG00000001491.1.
DR GeneTree; ENSGT00580000081600; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000001491; Expressed in intestinal epithelial cell and 13 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR025929; INSIG_fam.
DR PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1.
DR PANTHER; PTHR15301:SF10; INSULIN-INDUCED GENE 2 PROTEIN; 1.
DR Pfam; PF07281; INSIG; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW ECO:0000256|RuleBase:RU241113};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU241113};
KW Lipid metabolism {ECO:0000256|RuleBase:RU241113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Steroid metabolism {ECO:0000256|RuleBase:RU241113};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU241113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU241113}.
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 73..92
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 135..152
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
SQ SEQUENCE 229 AA; 25327 MW; 862D0239CC8F30C6 CRC64;
MSDSAVIRGQ PKMPRPNWGP YISVITNRTT NLVIRGAMLF SVGVFLALVL NLLQVQRNVT
LFPPDVISSI FSSAWWVPPC CGTASALIGL LYPCIDSRLG EPHKFKREWS SVMRCVAVFV
GINHASAKVD FANNVQLSLT LAALSVGLWW TFDRSRSGFG LGVSIALLAT LATQLLVYNG
VFQYTSPDFL YIRSWLPCIF FAGVITMGNI GRQLALYEGK FCQEKTHQD
//