ID G3NI21_GASAC Unreviewed; 2151 AA.
AC G3NI21;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Si:ch73-194h10.2 {ECO:0000313|Ensembl:ENSGACP00000004981.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000004981.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000004981.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000004981.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSGACT00000004996.1; ENSGACP00000004981.1; ENSGACG00000003775.1.
DR GeneTree; ENSGT00940000157247; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000003775; Expressed in intestinal epithelial cell and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF24; UNCONVENTIONAL MYOSIN-VIIB ISOFORM X1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 61..736
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1002..1232
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1237..1544
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1542..1608
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1681..1831
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1837..2140
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2064..2093
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 611..633
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 155..162
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2151 AA; 246088 MW; 3B2DB75658AF64BD CRC64;
MLHLSKGDFV WVDIGAHVPI GAEVKVTDTG QFQLIDDEGK EHKINKKTEG AIRPMHPTSV
KGVDDMIRLG DLNEAGLLRN LLVRHKEGII YTYTGSILVA VNPYQLLPIY TVEQVHMYTD
RRLGELPPHV FAIADSCFFN MRRNQRNQCC VIRSGESGAG KTENTKLMLQ FLAAVSGQHS
WIEQQILEAN PILEAFGNAK TVRNDNSSRF GKYIDINFTK GGAIEGARIE QYLLEKSRVC
RQAPEERNYH IFYYMLMGMP AEQKKILSLG NAAEYKYLTM GKCTSCDGRD DVKEFAHFRS
ALKILMFTEN DSWEICKLLA AILHLGNVDF EATIVNNLEA CKILTSPNFN MASQLLEVEP
KALEKSLTQH SLMTGRESVT KPLTSAQAKD GKDAFVKAIY GRLFIWVVKK INAAVYKPPE
DGEEVRQSIG LLDIFGFENF NKNRLAFTAT LQPSVPLLLQ HVFKLEQDEY ARENIVWKQI
DYKDNQGTLD MLANKPLNML ALIDEESNFP KGTDSTLLHK LNQVHGKGDI YLCPKNNYET
QFGVKHFAGE VHYDSNGFLE KNRDAHSSDL INLMETSTNK LLKEAFHNAL SQGADGKKRV
PTLIGQFRQS LDSLMKTLTV CQPYFIRCIK PNDFKRPMLF DRELCMRQLR YSGMMETIRI
RKSGYPVRYT FSEFLNRYRV LLKTTLCDPK TQQKSKEECC DSICESILAE EGDWKRGKTK
IFLKDFHDTM LEVERMKELN EKALVIQKVM RAYKYRRQFL KKRAGALVIQ KCWRGHKGRK
LYKVVQLGFA RLQAQVRSRQ LQFRYEKQRK ASVVLQARVR GYQARKEWKR KRDAVILLQA
HARGGLARKA MKKRKTDHSI INILKLKKGA KSSLVLCAFV QMYLSAKEKE EEQRAVLERQ
KHLEEILRRR KEMEAKAQTE SITDQEMVDS IFDFLPGMVG GGQEGQAPVG YEKFEGRVTE
EIDIDEQPME EGLPQEDDDD LDEYSFSKFA SMYFQGAATH SHIRLRLRQP LLYHEDEGDV
LASLTVWWII LRFMGDLPDP KKRVQAQGGS PQERLMPQEL MSRNDRRLSH MVGLDQRVLR
NKKERKPSTV PEEPTQNRKA SIFTDLLTVS EDDDIMVGEG PTLDRPLTVL EKLHIIVGYA
IVRPELRDEI YCQICKQLQD NNTRNSYFRG WILMSLCLGI FPPSDRFIRY LQSFIRFAPG
GYAAHCAERL RRTAMNGVRG EPPAWLELQA IKTKKPMIVS VSLMDGRSIN LPVDSASTSK
EICQLLSNKV KLKDTFGFSV YVALYEKVWA LGGGREHVMD AISQCEQEVK RRGGQEQHAP
WRLFFRKEVF TPWHDCKEDT ISTDLIYRQF IHGLKCGEYQ SKKEDDLVQL AAKHLYIQNG
ADSSAEHVKE AVQDCVNNTL LEAKSEGKWL QMVSAAHSQG PYLSSRQKAE SVKAEMVDYA
RETWPMFFSR FFEVVKLSGP ALPKSKFIVA INWTGITFLD EREKRLLELS FPEVTGVHTM
REAKGSGQAV NLLTLKGDFS LSGGTAEDMA ELVTMFLSGL RERSKYAVTL KEADRQDDPT
FLSFKKGELI IIIKDDEFSE QRGWIKGQSE STRQTGAVPT EAILILPTLS KPTNAVMSLL
NLSPNQRENI IRENQKETGT MERLAPATLR EFSLEYFRQP SKDVNRQVMS RNAAPERLWA
NSREPIRQPL LKKLVGNPEL SHKACLAFTA ILKYMGDYPT KQTQSPLELT DQIFGPATKN
EALRDEIYCQ IMKQMSGNNN RLSVEQGWQL LWLCCGLFAP SQSLLRHARR FLETRSREPL
AADCLQRLQS SLSRMEPRKL PPHQTEVDAI QQNSTQIFHK IHFPNDTEEI FEVATNTRIK
DLIQNITKKL SLASADGFSI FVKTQDTVLS LNDTDYFFDS LRQITDWSKK AKRIKDGGPV
NIAYLVFFMR KLWFNVIPGR DAEADLIFHF PQELPKYLRG YHVCTKEEMV NIAALLFKIK
VGNDKSQLVM IPKMLKELVP ADQLKAMSEN EWKKTIVASY NKQAGTTVED AKVAFLKAVC
RWPTFGCAFF EVKQTSEPSF PDIVRIAVSK EGLTIIHPKS KEVLANHPFN RIANWCSGST
YFHMTIGNLV KGSKFLCETS LGYKMDDLIT SYVTMYLNEQ KVLQTRNQRF N
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