ID G3NJQ1_GASAC Unreviewed; 1055 AA.
AC G3NJQ1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
GN Name=FARP1 {ECO:0000313|Ensembl:ENSGACP00000005563.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000005563.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000005563.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000005563.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3NJQ1; -.
DR STRING; 69293.ENSGACP00000005563; -.
DR Ensembl; ENSGACT00000005579.1; ENSGACP00000005563.1; ENSGACG00000004228.1.
DR eggNOG; KOG3531; Eukaryota.
DR GeneTree; ENSGT00940000155318; -.
DR InParanoid; G3NJQ1; -.
DR OMA; NGHEDRK; -.
DR TreeFam; TF351276; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000004228; Expressed in zone of skin and 6 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17189; FERM_F1_FARP1; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 41..321
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 550..741
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 770..867
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 942..1039
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 373..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 119667 MW; 324522BE22D91364 CRC64;
MAEPEPMALG AGQRLGAPET LGISTLDPGH RPPAMPSGRH VTIRVRMLDD TEELFDVSQK
ASGKVLLDMV CSHMNLVEGD YFGLEFQNRQ KMMVWLDHVK PIMKQLRRPK QTILTFAVKF
FPPDHAQLLE ELTRYLFALQ IKQDVSCGRL TCNDTSAALM VSHIIQSEIG DFEESQCRSH
LLNNNYIPDQ IPLIDKIMEF HSKIIGQSPA ESDYQLLEVA RRLEMYGIRL HPAKDREGTR
LSLAVGHTGV LVLQGHSKIN AFNWSKVRKL SFKRKRFLIK LRPDPNSSPQ GTLEFLMGSR
DCCKVFWKIC VEYHAFFRLF EEPKPKPKPV LFTRGSSFRF SGRTQKQVID YVRESEFKKI
PFERKHSRVQ HNVRLSPLPC PRPQDVPTEE SVLVSAEDTS ASRTTSPSHQ RNGREDRAGP
VSMAEETRGS TPPTHPERQS TGPAFQAAAK GSCSSAPFTD RGAVCSEYNQ TMSPLAADPR
TEVAPNSPHP SASSGHSLGM VNGQRSLEPC GHSPDGRPPS PLTSPLLNHA GSVRTDEEDE
VRRKRFPTDR AYFIAKELLT TERTYLKDLE VVTVSFQSAV GQDEATPDSL MKNILCTFEP
LHKFHKGFLR EVEQRLSLWE GRSNAHIKGD YQRIGDVMLK NLQGLKPLTA NLHKQSEVLL
ELEKACRASR RLEGLCRDFE LQKVCYVPLN VFILRPLHRL SHYKQLLERL CKHYPATHVD
FRDCRAALAD VSEVVEQLQG SLIKMENFQK LLELKKDFIG VDNLVVPGRE FIRLGCLSKL
SGKGLQQRIF FLFNDVILYT SRGMMATNQF KVHGQLPLHG MTIRESEDEW GVPHAFTLVG
KQQSVVVAAS SLIEMEKWMD DIQVAIEMAN TSNGPSSDLL TSSLIDNKRP DVSSADAECE
DDVTASRTSL ERPAPHRGNT MVHVCWHRNT SVSMVDFSLA VENQLSGNLL RKFKNSNGWQ
KLWVVFTNFS LFFYKSHQDE YPLASLPLLG YSVTIPSETE NIHKEYVFKL HFKSHVYYFR
SESEYTFERW MEVIRSVTVP LGSARILNSR ESRPR
//
