ID G3NJU6_GASAC Unreviewed; 2059 AA.
AC G3NJU6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Dedicator of cytokinesis 9 {ECO:0000313|Ensembl:ENSGACP00000005608.1};
GN Name=DOCK9 {ECO:0000313|Ensembl:ENSGACP00000005608.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000005608.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000005608.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000005608.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 69293.ENSGACP00000005608; -.
DR Ensembl; ENSGACT00000005624.1; ENSGACP00000005608.1; ENSGACG00000004237.1.
DR eggNOG; KOG1997; Eukaryota.
DR GeneTree; ENSGT00940000155972; -.
DR InParanoid; G3NJU6; -.
DR OMA; NWGSGTE; -.
DR TreeFam; TF313629; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000004237; Expressed in muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 130..237
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 602..779
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1592..2020
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 250..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1222..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2059 AA; 234338 MW; 2D836C0CD168711D CRC64;
KPKVIEPLDY ENVLVQRKTQ ILSDVLRDML QFPLEDFEIS TLRRQGRTLY PTVPEGAERE
AQSLFVQECI KTYTSDWHVV NYKYEDYSGD FRQLPNKVSR PDKLAVHVFE VDEDVDKDED
ATSLGSQKGG ISKHGWLYKG NINSAISVTM RSFKRRYFHL TQLGDGSHNL NFYKDEKISK
EPKGTIFLDS CMGVVQNNKV RRFAFELKMQ DKSTYLLASD SEGEMEDWIN TLNKILHSSF
EVAMQEKRNG DIHDDEDLGK SDSSSGSMDS FQEIPFSSSQ SARDIESRMR NETRLKLFTL
DSDTQKLDFS GIEPDVKQFE EKFGKRVLVN CNDLSFNLQS CVAENEEGPT TNVEPFYVTL
SLFDIQNGKK ISSDFHVDLN HLSVRGMLPS NTTQYMNGGG DTHPEGPRLV HGVPEASMQY
PRQGVFSVTC PHPDIFLVAR IEKVLQGGIN HCAEPYMKSS DSTKVAQKVL KNAKLACCRL
GQYRMPFAWA ARSLFKDASG TLDKGARFSP LYRQDNNKLS NDDVLKLLAD FRKPEKMAKL
PVILGNLDVT IDNVAPDLTN CVTSSYIPVK QFEVSEKTSI FFEVEEFVPC IAKCSQPFTI
FNNHLYVYPK HLKYDSQKSF AKARNIAVCV EFKDSDEEEA VSLKRIYGRP GGPLFTKNAF
AAVLHHQQNP EFYDEFKIEL PTQLHEKHHL LFTFHHVSCE SNSKASTKKR DLVDTQVGYA
WLPLLKDGRV TMNESQIAVA ANLPAGYLNC QEAASKHSGP EVKWVDGGKP LFKVSTHLVS
TVYTQDQHLH NFFHHCQSIA ATPQVSGGQL VKFLKSLHAM ESHVMIKFLP TTLNQLFRVL
TSATQEEVAV NVTRVMIHIV AQCHEEGLEH YLRSYVKFVF KSEPQTSSPT RLVHEELAKA
MTAILKPSTD FLTSNKLLKY SWYFFEALVK SMAQYLIESC KVKLSRNQRF SASFHHTVET
LVNMMMPHIT QKYKDNLDAA RNANHSLAVF IKRCLNLMDR GFVFKQINNY INCFMPGDPK
TLFEFRFEFL RVVCYHEHYV PLNLPMPFGK GRIMRFQDLQ MDYSLTDDFC KNHFLVGLLL
REVSAALQEF REIRQIAIHV LKNLMIKHTF DERYTSKSQQ ARLATLYFPL FGLLQENVNR
LNVKEVSPFT VNHSNNNGRE DLLLSNALMT PPRSSTFLDT SLHKDVFGVI SGTFVDAASP
HASSTPNINS VRLAESRGSL ISTDSGNSLS EKNNDKSNSL DKNQAASTPG SSLLRCDKLD
QAEIKSLLMC FLHVLKSMSE DALFTYWNKA SSAELMDFFT LVEVCLHQFR YMGKRYIARN
QEGAGPVAHE RKSQTLPVSR NRAGMMHARL QQLSSLDNSY TFNHTYSHSD ADVLNQSLLE
ANVATEVCLT VLDTLSIFIM GFKTQLCTDH GHSPLMKKVF DVHLCFLRIN QSETALKQVF
TSLRTFIYKF PCTFFEGRAD MCAAFCCEIL KCCNSKLSSI RSDAAHLLYF LMKSNFDYTG
RKSFVRTHLQ VVIAVSQLIA DVIGIGSTRF QQSLSIINNC ANSDKTIKNT AFPSDVKDLT
KRIRTVLMAT AQMKEHERDP EMLVDLQYSL AKSYASTPEL RKTWVDSMAR IHVKNGDLSE
AAMCYVHVAA LVAEYLRRKG MFKQGCSAFR VVTPNIDEEA AMMEDVGMQD VHFNEDVLME
LLEECADGLW KAERYELISD IYKLIIPIYE KRRDFEKLAH LYDTLHRAYS KVTEVMHTGK
RLLGTYFRVA FFGQGFFEDE DGKEYIYKEP KFTPLSEISQ RLLKLYSDKF GQENVKIIQD
SGRINPKDLD SKYAYIQVTH VTPYLEEKEL VDRKTDFEKS HNIRRFVFEM PFTISGKKQG
GVEEQCKRRT ILTTTHCFPY VKKRIAVMYQ HHTDLSPIEV AIDEMSKKVA EIKHLCSSSD
VDMIRLQLKL QGSISVQVNA GPLAYARAFL DDASAKKNPD NKVKQLKEVF SRQFVEACGH
GLGINERLIK EDQQEYHDEM KASYRDLAKE LSIIMHEQIS PVEDGMKSVL PDSLQIFNAI
SGTPTSATIH GIPSSSSVV
//
