ID G3NKT4_GASAC Unreviewed; 948 AA.
AC G3NKT4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Nucleotide-binding oligomerization domain containing 1 {ECO:0000313|Ensembl:ENSGACP00000005947.1};
GN Name=NOD1 {ECO:0000313|Ensembl:ENSGACP00000005947.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000005947.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000005947.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000005947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3NKT4; -.
DR STRING; 69293.ENSGACP00000005947; -.
DR Ensembl; ENSGACT00000005964.1; ENSGACP00000005947.1; ENSGACG00000004511.1.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000157845; -.
DR InParanoid; G3NKT4; -.
DR OMA; AHWGMEK; -.
DR TreeFam; TF352118; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000004511; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08324; CARD_NOD1_CARD4; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF278; RNI-LIKE SUPERFAMILY PROTEIN; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 21..87
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 195..396
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 948 AA; 106266 MW; 8778284385E341C5 CRC64;
LHQQGSVNMG EMEGTKVPYL KILTYHRELL VSQLRSIQCI LDNLLACSFV CEEDVEIVLR
SATRTDQVRK ILELVQCKGE EACEYFIYVI YKVRDAYVDL QPWLKEINYS PSSDATALSV
VNTDPISRYS EKLRHEMSRD TCFIMSYGQR EETRLEDLYT DTQMALLDDC NEHLGFLGSL
DELFADQAVF NPQGEIIYVI GDAGVGKSIL LQRLQNLWSK KDLQADAIFF FKFRCRMFSL
FKDTDQISLR DLLFKYNCFP DHDPNNEVFD YILRFPEKVL FTFDGYDEIQ MNDLLNAPEV
VSPDAKAHPV QLLDSLLGGK LLKGSQKVLT ARTGTEIQST VIRKKVVLRG FSPAHLKTYI
SIHFKEQEHR DQVSVQLDAS PHLCGLCSTP LFCWIVLKSF RHLHTMHDSF HLPETCVTLT
DIFLLLCEVC LSRSGSSAPS LLKKSPRCVS ETFVAGLRPL AAFAKVALRG MERSSFVYSQ
EELMECGLTE EDLTLGFLRP VGECDASGGP ATFEILHIIL HSFLAAFALV LDEQAAAGSV
LKFFTECRRK REARCAPCLS CFCGSSKSGE KTLFETNEHF QFTNLFLCGL LSKAHAGLME
HLVSPVLLRK KRALLKSYLS TSVKSHLVGL PHHNSGEGQK VHVLPNFLWM LRCIFETGSR
DIAQMTAKGI TAGFIKLGYC NVFSGDCTAL NFVLQHRQKL LGLDMDNNNI SDYGVKQLRP
SFCKMTIVRL CVNHLSDSSV EVLAEELCKH KVVEVLGLYN NYITDAGAKL VAQIIEECPK
LRVVKIGKNK ITAVGGRYLA SAIQKSASIF DVGMWGNSIG DEGAQAFAEA LRNHPRLTNL
SLAANGITSK GGRCLAEALK ENSVLRIFWL VQNELNDDAA PHLAELVQAN TGLSHLWLIN
NQFTVDGIKI LSAALNVNTA LKEICLKANR LSEEEEKQFV GDKRLRFH
//
