ID G3NNJ4_GASAC Unreviewed; 1366 AA.
AC G3NNJ4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Pleckstrin homology-like domain, family B, member 1b {ECO:0000313|Ensembl:ENSGACP00000006908.1};
GN Name=PHLDB1 {ECO:0000313|Ensembl:ENSGACP00000006908.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000006908.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000006908.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000006908.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSGACT00000006925.1; ENSGACP00000006908.1; ENSGACG00000005214.1.
DR eggNOG; ENOG502QPZY; Eukaryota.
DR GeneTree; ENSGT00940000155231; -.
DR InParanoid; G3NNJ4; -.
DR OMA; DKKSPFQ; -.
DR TreeFam; TF329165; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000005214; Expressed in zone of skin and 9 other cell types or tissues.
DR CDD; cd22713; FHA_PHLB1; 1.
DR CDD; cd14673; PH_PHLDB1_2; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037810; PHLDB1/2/3_PH.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR12156:SF23; PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 1; 1.
DR PANTHER; PTHR12156; PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 1242..1359
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 159..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1134..1186
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 243..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1366 AA; 150429 MW; 3BABAF2328D71738 CRC64;
MDRLNRNMPE CGLQTHQVLK STALDLIESG KGLKFQAERP HLVSLGSGRL STAITLLPLP
EGRTTLGHGN MDISIQGPGV EAQHCYIDNR SKVITLHPCG NLCSVDGLQV SQPVRLSQGC
MLCFGQSAFF RFNHPEEACR MKSMLPHGGG VSTGDYRLRP GTKPPCIPPK HGNKSPLTLP
AGARAQSEHS AIVSSIERDL QDIMDSLAMD DPQPSKPPPR SSLLSPVLNG GGRYLLSPPA
SPGAMSVGSS YENASPPFSP LSSPSGASSG GFTSPSPGGP QEQSLSQPPV PLRSSSYNFT
AQPPPMPHPR SALKVQESPR LQRRVMKEAP QSPKPGRRGL GQEGPESPRL LSSSESLSGR
TAALSSPRPA IKFPACPSPP GHRTKTATVL QERPASPFRD WTGPADCPPG QLSHPSRAFQ
GSPLQQQQPP RLLQPPESPR TPRKNTELNG GGMRELPPLS PSMARRGVPG ALPTLRTPDS
PSSLGKFLIP ESPRLRRRAG SASEEPAGGR GVLARSPSPT MEVGGGGGAR KASLGNSLSP
AYSLGSLPGS SPAASPRSRR KASGGRPHPP MRERKNSISE ISDNEDELLE YHRRQREERL
REQEMERLER QRLETILHLC AEYNKGETSC DPLPSGSTGF PGGPSNDNAI GGPASSAAGG
LHLLQRQRES DEENLKEECS STESTHQEHE DSSGLELSYL EEERVRVLAR IDELKSRLTE
LEQQLQEAKQ EAEMERALLQ GERQAELDQI EAETDIITQL QRKLDELESA IQREKEKDGD
ALETGTKKFE DLEFQQLERE SSLEEERETI SQQLLQERAE YHGSVSRRKE KVSALENQAG
QLGLQATQEY ERLAGDRGLA LQMLHKEKER LSALEKRYHG LTGGRSFPKS STAMREYPSE
GSRPPLPKLD LEQWYQELMS GSGPLGPPSL PATALSGRRP ALQGDGFTLL PPPPRGSAPS
WKESRPPPST GACLEKGPHH LTQSPLLATN STGSLPRNLA TTQDIEAKRQ IALQQKAGHQ
VIEEQRRRLA ELKQRAAVEA QCQWEALRGS QSQLVASSTS PPSYSPGAAY GFGPPPLVHH
SILHHQPPAA GEQPYDTLSL ESSDSMDTSV STGNNSACSP DYMSSVGGAD AAKIEEMEKM
LREAQMEKAR LIESRERETV ARRHMLEEER RRREDAEKRL QEETFHRQQL VDKEVKMRAK
NFSQARPMTR YLPIRKEEFD LRSHVESSGH SVETCYHVLL NEKVCRGYLV KMGGKIKSWK
KRWFVFDRLK RTFSYYVDKH ESKLKGVIYF QAIEEVYYDH LRSATKVHFL RSVLFAAVTE
SPNPSLTFCV KTHDRLYYMV APAADAMRIW MDVIVTGAEG YTQFMN
//
