ID G3NTJ6_GASAC Unreviewed; 494 AA.
AC G3NTJ6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Angiopoietin-2 {ECO:0000256|ARBA:ARBA00015280};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000008664.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000008664.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000008664.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; G3NTJ6; -.
DR STRING; 69293.ENSGACP00000008664; -.
DR Ensembl; ENSGACT00000008683.1; ENSGACP00000008664.1; ENSGACG00000006549.1.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000158430; -.
DR InParanoid; G3NTJ6; -.
DR OMA; EQKYRIY; -.
DR TreeFam; TF336658; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 4.10.530.10; Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR19143:SF199; ANGIOPOIETIN-2; 1.
DR PANTHER; PTHR19143; FIBRINOGEN/TENASCIN/ANGIOPOEITIN; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 4: Predicted;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..494
FT /note="Angiopoietin-2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003448780"
FT DOMAIN 273..493
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT COILED 178..244
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 494 AA; 55961 MW; E0245E4304D5B9C8 CRC64;
VKSSAMKMPH ANLLVLAFCL VVGTGHSVVA KRQYQIQNGP CSYTFLLPEQ DNCQTQSSNY
AVQKDGPGDN EESTQRLEQL EIIMENNTQW LHKLENYIQD SMKQDMIHLQ HTAVQNHTAT
MIEIGTNLLS QTAEQTRKMS SVEAQVIRHS TRLERQLLEN SLSTNKLEKQ LIVQTNDISK
LNDKNSFLEK KVDEMEQQRQ VELKMLRNEK EQLLALILRQ TAIIGELEQQ LLKVSSNNTA
LQRQQQDLLD TVNNLIHTVS IGSAPASKTV MMQDTPTAFT DCAAVFKSGN TQSGVYTLTL
PNNTTEVKAF CDMQTEGGGW TVIQKRFDGH VDFHRTWQEY RKGFGDPSGE FWLGNEFVSR
LSIQQPYRLR IQLSDWEGNS AFSQYDQFSL EGEALNYRIH LKGFSGTAGK ISSIGQPGSD
FSTKDKDNDK CVCKCSQLTT GGWWFDACGP SNLNGMFYQQ GQNSNRFNGI KWYYWKGSGY
SLQSTTMMIR PADF
//
