ID   G3NU76_GASAC            Unreviewed;       282 AA.
AC   G3NU76;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Dimethylarginine dimethylaminohydrolase 1 {ECO:0000313|Ensembl:ENSGACP00000008894.1};
GN   Name=DDAH1 {ECO:0000313|Ensembl:ENSGACP00000008894.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000008894.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000008894.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000008894.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DDAH family.
CC       {ECO:0000256|ARBA:ARBA00008532}.
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DR   AlphaFoldDB; G3NU76; -.
DR   STRING; 69293.ENSGACP00000008894; -.
DR   Ensembl; ENSGACT00000008914.1; ENSGACP00000008894.1; ENSGACG00000006704.1.
DR   eggNOG; ENOG502QWPA; Eukaryota.
DR   GeneTree; ENSGT00940000157892; -.
DR   InParanoid; G3NU76; -.
DR   OMA; HRYTHAI; -.
DR   TreeFam; TF314737; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000006704; Expressed in liver and 12 other cell types or tissues.
DR   GO; GO:0016403; F:dimethylargininase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR033199; DDAH-like.
DR   PANTHER; PTHR12737; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE; 1.
DR   PANTHER; PTHR12737:SF17; N(G),N(G)-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1; 1.
DR   Pfam; PF19420; DDAH_eukar; 1.
DR   SUPFAM; SSF55909; Pentein; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   ACT_SITE        170
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR633199-1"
FT   ACT_SITE        271
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR633199-1"
FT   BINDING         28
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT   BINDING         70
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT   BINDING         75..76
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT   BINDING         95
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT   BINDING         142
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
FT   BINDING         265
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR633199-2"
SQ   SEQUENCE   282 AA;  30815 MW;  315792DAA00DD98B CRC64;
     MAGLMSGFGH YTHAVVRGIP ASLAKEALRS CQAEVDLAEA RREHEEYVEV LGTRLGLEVV
     ELPADESLPD CVFVEDAAVV CGDTALITRP GAESRRRETE TMKSALKELN LNIVEMTDEK
     ATLDGGDVLF TGREFFVGLS KRTNQRGAEI LADAFKDYAV STVPVLEGLH LKSFCSMGGP
     GLIVIGSSEP AQKALKIMQQ MSDHRYDKLT VPDDLAANCI YMNLPNKGHV LLHPTAEQYP
     ESAKVFEKLK DYMLIPVCNM QKVKVDGALT CCSVLINKKA NI
//