ID   G3NXS1_GASAC            Unreviewed;       624 AA.
AC   G3NXS1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=EPS8-like 3b {ECO:0000313|Ensembl:ENSGACP00000010141.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000010141.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000010141.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000010141.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the EPS8 family.
CC       {ECO:0000256|ARBA:ARBA00006197}.
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DR   AlphaFoldDB; G3NXS1; -.
DR   STRING; 69293.ENSGACP00000010141; -.
DR   Ensembl; ENSGACT00000010163.1; ENSGACP00000010141.1; ENSGACG00000007643.1.
DR   eggNOG; KOG3557; Eukaryota.
DR   GeneTree; ENSGT00940000158169; -.
DR   InParanoid; G3NXS1; -.
DR   OMA; LGDSWNI; -.
DR   TreeFam; TF313069; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000007643; Expressed in intestinal epithelial cell and 1 other cell type or tissue.
DR   CDD; cd01210; PTB_EPS8; 1.
DR   CDD; cd11764; SH3_Eps8; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR039801; EPS8-like.
DR   InterPro; IPR033928; EPS8_PTB.
DR   InterPro; IPR035462; Eps8_SH3.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR013625; PTB.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041418; SAM_3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12287:SF22; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 3; 1.
DR   PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR   Pfam; PF08416; PTB; 1.
DR   Pfam; PF18016; SAM_3; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          471..530
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          195..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          442..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          518..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  70056 MW;  579404452DA81CD3 CRC64;
     MFGNGTHFSF SPRGFSPEDL PPQRRAFQQD DLNVAPLQRN NMSRPSGKSI YMQRKEYSEV
     LDRHPDNFHV RVEHLITCKL DGQEVKTVDD CLAKLKRLDA KGRLWPQEMG MEIQGGYLLL
     SDIETKSELE SLPLRSILET KAVLDSCAYN SLLILTVQER GRRVPQVFMF QCEETGADLI
     KADLENIIGQ QVSGSFRQAG PRPVQRERSP PPLDQPAAGW RSREPGGLPQ GQWRRSLQVE
     NVPPPPYVGS QEAEMYRPGL RGSYIDPEAA EQMEIERNTD ILNHILNDVE FFMDKVSAAN
     ETSLPEVKKK KKKKSKKNEA PAIILPPWEE YVSFLQRVKY GFNLLAQLDG CLSGPTAPDY
     VHIFFDSLGA ILPRYPADLP PTVLSPLLTE AALQLMCEVV SPEEDLLWRS LGDSWNIPGS
     RWPDDDVPPY IPEFYNGWQP PPPSSMPSPL PYQSGPSSTS SSQHFPSSPR EPPLYMQVIY
     DFVAKNSQEL SVMKGDVVQV VQKSKQWWLV RNGGGEEGHI PQNVLEPMQS RGPMEDLPRD
     SRRPVTLDMN SSSTEVKAWL EHKGFSRITV SSLGVLTGNL LLGMTKDEIR TVCPEEGGKV
     FFQLQGIKSA IALASEPSGL YGRY
//